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利伐沙班在抗凝血酶缺乏情况下用于不明原因肺栓塞的应用

The Use of Rivaroxaban for Unprovoked Pulmonary Embolism in the Setting of Antithrombin Deficiency.

作者信息

Gryn Oscar J, Nguyen Trivian, Frankova Daniela

机构信息

Internal Medicine, Des Moines University, Des Moines, USA.

Internal Medicine, Mercyone Medical Center, Des Moines, USA.

出版信息

Cureus. 2020 Jun 11;12(6):e8560. doi: 10.7759/cureus.8560.

DOI:10.7759/cureus.8560
PMID:32670697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7358900/
Abstract

A 24-year-old woman with antithrombin (AT) deficiency presented with right-sided pleuritic chest pain of five days duration with diagnosis of pulmonary embolism (PE) made at an outside hospital. After discussion of treatment options with the patient, her treatment was changed to rivaroxaban protocol. The case illustrates an appropriate treatment plan for patients with AT deficiency presenting with unprovoked PE, especially when prioritizing ease of use.

摘要

一名24岁的抗凝血酶（AT）缺乏症女性患者，因右侧胸膜炎性胸痛持续5天，在外院被诊断为肺栓塞（PE）。在与患者讨论治疗方案后，她的治疗改为利伐沙班方案。该病例说明了针对无诱因PE的AT缺乏症患者的适当治疗计划，特别是在优先考虑易用性的情况下。

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本文引用的文献

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Risk of Recurrent Venous Thromboembolism After an Initial Episode: Risk Stratification and Implications for Long-term Treatment.首发静脉血栓栓塞事件后复发的风险：风险分层与长期治疗的意义。
Curr Cardiol Rep. 2019 Mar 4;21(4):24. doi: 10.1007/s11886-019-1111-2.
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Successful treatment of a massive pulmonary embolism using rivaroxaban in a patient with antithrombin III deficiency.利伐沙班成功治疗抗凝血酶III缺乏患者的大面积肺栓塞。
J Cardiol Cases. 2017 Jul 26;16(5):144-147. doi: 10.1016/j.jccase.2017.06.008. eCollection 2017 Nov.
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Efficacy of Oral Factor Xa Inhibitor for Venous Thromboembolism in a Patient with Antithrombin Deficiency.
A Review of the Incidence Diagnosis and Treatment of Spontaneous Hemorrhage in Patients Treated with Direct Oral Anticoagulants.
直接口服抗凝剂治疗患者自发性出血的发生率、诊断与治疗综述
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口服Xa因子抑制剂对一名抗凝血酶缺乏患者静脉血栓栓塞症的疗效
Intern Med. 2018 Jul 15;57(14):2025-2028. doi: 10.2169/internalmedicine.0483-17. Epub 2018 Mar 9.
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Recurrent Thrombosis: A Case of Hereditary Thromboembolism.复发性血栓形成：一例遗传性血栓栓塞病例
Am J Case Rep. 2017 Nov 2;18:1157-1159. doi: 10.12659/ajcr.906035.
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The Successful Prevention of Thromboembolism Using Rivaroxaban in a Patient with Antithrombin Deficiency during the Perioperative Period.利伐沙班成功预防抗凝血酶缺乏患者围手术期血栓栓塞
Intern Med. 2017 Sep 1;56(17):2339-2342. doi: 10.2169/internalmedicine.8487-16. Epub 2017 Aug 10.
6
Edoxaban Was Effective for the Treatment of Deep Vein Thrombosis and Pulmonary Thromboembolism in a Cancer Patient with Antithrombin III Deficiency.依度沙班对一名抗凝血酶III缺乏的癌症患者的深静脉血栓形成和肺血栓栓塞治疗有效。
Intern Med. 2016;55(22):3285-3289. doi: 10.2169/internalmedicine.55.7314. Epub 2016 Nov 15.
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The use of direct oral anticoagulants in inherited thrombophilia.直接口服抗凝剂在遗传性血栓形成倾向中的应用。
J Thromb Thrombolysis. 2017 Jan;43(1):24-30. doi: 10.1007/s11239-016-1428-2.
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PROS1 mutations associated with protein S deficiency in Polish patients with residual vein obstruction on rivaroxaban therapy.在接受利伐沙班治疗但仍有静脉阻塞的波兰患者中，与蛋白S缺乏相关的PROS1突变。
Thromb Res. 2014 Jul;134(1):199-201. doi: 10.1016/j.thromres.2014.01.023. Epub 2014 Jan 23.
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Effectiveness and safety of novel oral anticoagulants as compared with vitamin K antagonists in the treatment of acute symptomatic venous thromboembolism: a systematic review and meta-analysis.新型口服抗凝剂与维生素 K 拮抗剂治疗急性有症状静脉血栓栓塞症的有效性和安全性：系统评价和荟萃分析。
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Oral rivaroxaban for symptomatic venous thromboembolism.口服利伐沙班治疗有症状的静脉血栓栓塞症。
N Engl J Med. 2010 Dec 23;363(26):2499-510. doi: 10.1056/NEJMoa1007903. Epub 2010 Dec 3.