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依度沙班对一名抗凝血酶III缺乏的癌症患者的深静脉血栓形成和肺血栓栓塞治疗有效。

Edoxaban Was Effective for the Treatment of Deep Vein Thrombosis and Pulmonary Thromboembolism in a Cancer Patient with Antithrombin III Deficiency.

作者信息

Kawano Hiroaki, Maemura Koji

机构信息

Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.

出版信息

Intern Med. 2016;55(22):3285-3289. doi: 10.2169/internalmedicine.55.7314. Epub 2016 Nov 15.

DOI:10.2169/internalmedicine.55.7314
PMID:27853070
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5173495/
Abstract

A 57-year-old man with antithrombin III deficiency with deep vein thrombosis and pulmonary thromboembolism after surgery for colon cancer was managed with warfarin and inferior vena cava filtration. After starting chemotherapy for liver metastasis, the control of his prothrombin time-international normalized ratio in response to warfarin began to fluctuate. Warfarin was changed to edoxaban (an oral direct Factor Xa inhibitor), and he had no recurrence of venous thromboembolism or bleeding for approximately 1 year. We conclude that edoxaban could be a useful treatment option for complicated patients with deep vein thrombosis.

摘要

一名57岁男性，患有抗凝血酶III缺乏症，在结肠癌手术后发生深静脉血栓形成和肺血栓栓塞，接受华法林和下腔静脉滤器治疗。在开始针对肝转移的化疗后，他的凝血酶原时间-国际标准化比值对华法林的反应开始波动。将华法林换成依度沙班（一种口服直接Xa因子抑制剂）后，他在大约1年内没有再次发生静脉血栓栓塞或出血。我们得出结论，依度沙班可能是治疗复杂深静脉血栓形成患者的一种有用选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0976/5173495/3226915ca143/1349-7235-55-3285-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0976/5173495/fd8db1409a7b/1349-7235-55-3285-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0976/5173495/01ec9e1fc32f/1349-7235-55-3285-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0976/5173495/3226915ca143/1349-7235-55-3285-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0976/5173495/fd8db1409a7b/1349-7235-55-3285-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0976/5173495/01ec9e1fc32f/1349-7235-55-3285-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0976/5173495/3226915ca143/1349-7235-55-3285-g003.jpg

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