Suvarna Chintada, Chaitanya Nallan Csk, Ameer Shaik, Inamdar Pavitra, Alugubelli Swetha, Bhagyanagar Alakananda
Department of Oral Medicine and Radiology, Panineeya Institute of Dental Sciences and Research Centre, Hyderabad, Telangana, India.
Clinical preceptor, Rutgers School of Dental Medicine, Rutgers University, Newark, New Jersey, USA.
J Int Soc Prev Community Dent. 2020 Apr 2;10(2):127-133. doi: 10.4103/jispcd.JISPCD_424_19. eCollection 2020 Mar-Apr.
The term chemoprevention denotes the use of specific natural or synthetic chemical agents to prevent carcinogenesis. Chemoprevention may help delay the process of carcinogen activation and prevent the conversion of preneoplastic cells. These agents play an active role in the secondary level of prevention and reduce malignancy-associated morbidity and mortality. A new term, "prophylactic antioxidant therapy," was coined and proposed. This review has assessed all major chemopreventive agents used for oral premalignancy and malignant conditions, which will reduce the economic burden on the patients.
A systematic literature search was performed using PubMed, Medline, Embase, Cochrane Library, and EBSCO search, with language restriction to English. The search incorporated published literature from 1990 to 2018 using the medical subject heading terms. Literature search was performed using the following keywords: Chemoprevention, Premalignancy, and Oral Malignancy.
Of 99 publications related to the search strategy, 45 full articles relevant to the chemopreventive agents in premalignacy and oral malignancy were acquired for further inspection. Of the 45 articles, 30 met the inclusion criteria. Data were collected, and a brief summary of the studies regarding different chemopreventive agents that were most commonly used in oral premalignancy and malignancies was written.
This review suggests administration of major chemopreventive agents for superior prognosis in individuals with an elevated risk of premalignancy and malignancy.
化学预防一词是指使用特定的天然或合成化学制剂来预防癌症发生。化学预防可能有助于延缓致癌物激活过程，并防止癌前细胞的转化。这些制剂在二级预防层面发挥积极作用，降低与恶性肿瘤相关的发病率和死亡率。一个新术语“预防性抗氧化剂疗法”被创造并提出。本综述评估了用于口腔癌前病变和恶性疾病的所有主要化学预防剂，这将减轻患者的经济负担。
使用PubMed、Medline、Embase、Cochrane图书馆和EBSCO进行系统的文献检索，语言限制为英语。检索纳入了1990年至2018年使用医学主题词的已发表文献。使用以下关键词进行文献检索：化学预防、癌前病变和口腔恶性肿瘤。
在与检索策略相关的99篇出版物中，获取了45篇与癌前病变和口腔恶性肿瘤化学预防剂相关的全文进行进一步检查。在这45篇文章中，30篇符合纳入标准。收集了数据，并撰写了关于口腔癌前病变和恶性肿瘤中最常用的不同化学预防剂的研究简要总结。
本综述表明，对于癌前病变和恶性肿瘤风险升高的个体，使用主要化学预防剂可获得更好的预后。
