Appl Opt. 2020 Jul 10;59(20):6124-6130. doi: 10.1364/AO.395067.
Metal-phenolic networks (MPNs) have been exploited to be a versatile coating film to fabricate core-shell structure due to their general adherent properties. Herein, gold nanocuboid (GNCB) wrapped by MPNs (GNCB at MPNs) are prepared by a facile encapsulation method for surface-enhanced Raman scattering (SERS) analysis. The MPN coating not only reshapes the electric field distribution around the nanostructures but also allows the substrate to adsorb more analytes, both of which contribute to the superior SERS activity of GNCB at MPNs. The SERS signals induced by plasmonic nanostructures increase four- to sixfold after MPN coating, reaching a maximum Raman enhancement factor calculated to be 9.47×10. Moreover, the core-shell SERS substrate also demonstrates improved biocompatibility (∼fivefold increase) that facilitates the reliable SERS analysis of cancer cells and further diverse biomedical applications.
金属 - 酚醛网络 (MPNs) 因其普遍的附着性能而被用于制造核壳结构的多功能涂层膜。在此，通过简便的封装方法制备了被 MPNs 包裹的金纳米立方 (GNCB)（MPNs 中的 GNCB），用于表面增强拉曼散射 (SERS) 分析。MPN 涂层不仅重塑了纳米结构周围的电场分布，而且还允许基底吸附更多的分析物，这两者都有助于提高 GNCB 在 MPNs 中的优越 SERS 活性。在 MPN 涂层后，由等离子体纳米结构引起的 SERS 信号增加了四到六倍，达到了计算出的最大拉曼增强因子为 9.47×10。此外，核壳 SERS 基底还表现出改善的生物相容性（增加约五倍），这有助于可靠地进行癌细胞的 SERS 分析以及进一步的各种生物医学应用。
