Mikati Nancy, Callaway Clifton W, Coppler Patrick J, Elmer Jonathan
Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, USA.
Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, USA; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, USA; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, USA.
Resuscitation. 2020 Sep;154:26-30. doi: 10.1016/j.resuscitation.2020.07.004. Epub 2020 Jul 13.
Resuscitation research is inconsistent in how emergency department (ED) arrests are classified. We tested whether clinical features of ED arrests more closely resembled out-of-hospital cardiac arrest (OHCA) or in-hospital cardiac arrest (IHCA).
We performed a retrospective study including all patients resuscitated from cardiac arrest at a single academic medical center from January 2010 to December 2019. We abstracted clinical information from our prospective registry. We used unsupervised learning (k-prototypes) to identify clusters within the OHCA and IHCA cohorts. We determined the number of subgroups using scree plots. We assigned individual ED arrest patients the nearest OHCA or IHCA cluster based on the shortest Gower distance from that patient to the nearest cluster center. In our secondary analysis, we determined the optimal number of clusters in each of the 3 arrest cohorts, and then calculated the mean Gower distances with the standard deviation (SD) between cluster centers (ED-IHCA, ED-OHCA, IHCA-OHCA).
We included 2723 patients: 372 (14%) ED arrests, 1709 (63%) OHCA, and 642 (23%) IHCA. We identified 3 clusters of OHCA patients, and 4 clusters of IHCA patients. Of ED arrest cases, 292 (78%) most closely resembled an IHCA cluster and 80 (22%) most closely resembled an OHCA cluster. Mean (SD) Gower distance between ED arrest and IHCA centers was 0.33 (0.2). Mean Gower distances between ED arrest-OHCA centers and between IHCA-OHCA centers were 0.41 (0.11).
Across multiple aggregated measures, ED arrests resemble IHCA more than OHCA.
复苏研究在急诊科(ED)心脏骤停的分类方式上并不一致。我们测试了ED心脏骤停的临床特征是否更类似于院外心脏骤停(OHCA)或院内心脏骤停(IHCA)。
我们进行了一项回顾性研究,纳入了2010年1月至2019年12月在一家学术医疗中心从心脏骤停中复苏的所有患者。我们从前瞻性登记处提取了临床信息。我们使用无监督学习(k-原型)来识别OHCA和IHCA队列中的聚类。我们使用碎石图确定亚组的数量。我们根据个体ED心脏骤停患者到最近聚类中心的最短Gower距离,将其分配到最近的OHCA或IHCA聚类中。在我们的二次分析中,我们确定了三个心脏骤停队列中每个队列的最佳聚类数量,然后计算聚类中心之间(ED-IHCA、ED-OHCA、IHCA-OHCA)的平均Gower距离及其标准差(SD)。
我们纳入了2723例患者:372例(14%)为ED心脏骤停,1709例(63%)为OHCA,642例(23%)为IHCA。我们识别出3个OHCA患者聚类和4个IHCA患者聚类。在ED心脏骤停病例中,292例(78%)最类似于IHCA聚类,80例(22%)最类似于OHCA聚类。ED心脏骤停与IHCA中心之间的平均(SD)Gower距离为0.
33(0.2)。ED心脏骤停-OHCA中心之间以及IHCA-OHCA中心之间的平均Gower距离为0.41(0.11)。
通过多种综合测量方法,ED心脏骤停更类似于IHCA而非OHCA。