University of Nottingham, United Kingdom (R.J.F., A.B., N.C., S.L., M.F.W.).
King's College London, United Kingdom (L.P., A.H., A.R.).
Circ Cardiovasc Qual Outcomes. 2020 Aug;13(8):e006395. doi: 10.1161/CIRCOUTCOMES.119.006395. Epub 2020 Jul 17.
Implementation of stroke early supported discharge (ESD) services has been recommended in many countries' clinical guidelines, based on clinical trial evidence. This is the first observational study to investigate the effectiveness of ESD service models operating in real-world conditions, at scale.
Using historical prospective data from the United Kingdom Sentinel Stroke National Audit Programme (January 1, 2016-December 31, 2016), measures of ESD effectiveness were "days to ESD" (number of days from hospital discharge to first ESD contact; n=6222), "rehabilitation intensity" (total number of treatment days/total days with ESD; n=5891), and stroke survivor outcome (modified Rankin scale at ESD discharge; n=6222). ESD service models (derived from Sentinel Stroke National Audit Programme postacute organizational audit data) were categorized with a 17-item score, reflecting adoption of ESD consensus core components (evidence-based criteria). Multilevel modeling analysis was undertaken as patients were clustered within ESD teams across the Midlands, East, and North of England (n=31). A variety of ESD service models had been adopted, as reflected by variability in the ESD consensus score. Controlling for patient characteristics and Sentinel Stroke National Audit Programme hospital score, a 1-unit increase in ESD consensus score was significantly associated with a more responsive ESD service (reduced odds of patient being seen after ≥1 day of 29% [95% CI, 1%-49%] and increased treatment intensity by 2% [95% CI, 0.3%-4%]). There was no association with stroke survivor outcome measured by the modified Rankin Scale.
This study has shown that adopting defined core components of ESD is associated with providing a more responsive and intensive ESD service. This shows that adherence to evidence-based criteria is likely to result in a more effective ESD service as defined by process measures. Registration: URL: http://www.isrctn.com/; Unique identifier: ISRCTN15568163.
许多国家的临床指南都推荐实施脑卒中早期支持出院(ESD)服务,这是基于临床试验证据。这是第一项在真实环境中大规模调查 ESD 服务模式有效性的观察性研究。
使用英国 Sentinel 脑卒中国家审计计划(2016 年 1 月 1 日至 2016 年 12 月 31 日)的历史前瞻性数据,ESD 有效性的度量指标包括“ESD 天数”(从出院到首次 ESD 接触的天数;n=6222)、“康复强度”(治疗总天数/有 ESD 的总天数;n=5891)和脑卒中幸存者结局(ESD 出院时改良 Rankin 量表评分;n=6222)。ESD 服务模式(源自 Sentinel 脑卒中国家审计计划的急性后期组织审计数据)通过 17 项评分进行分类,反映了对 ESD 共识核心要素(基于证据的标准)的采用。由于患者在英格兰中部、东部和北部的 ESD 团队中进行了聚类,因此进行了多层次建模分析(n=31)。ESD 共识评分的差异反映了各种 ESD 服务模式的采用。在控制患者特征和 Sentinel 脑卒中国家审计计划医院评分的情况下,ESD 共识评分增加 1 个单位与更响应的 ESD 服务显著相关(降低≥1 天后就诊的可能性为 29%[95%CI,1%-49%],治疗强度增加 2%[95%CI,0.3%-4%])。与改良 Rankin 量表测量的脑卒中幸存者结局无关联。
本研究表明,采用 ESD 的明确核心要素与提供更响应和强化的 ESD 服务相关。这表明,遵循基于证据的标准可能会导致更有效的 ESD 服务,如过程指标所定义的。注册:网址:http://www.isrctn.com/;唯一标识符:ISRCTN15568163。