Hamilton-Bruce M A, Black A B
Department of Neurology, Queen Elizabeth Hospital, Adelaide, SA.
Clin Exp Neurol. 1988;25:97-102.
The flight of colours (FOC) test was compared with visual evoked potentials (VEPs) in 135 patients in a 2 year prospective study, to determine whether the FOC test is a sensitive and reliable alternative. We obtained an 80% overall agreement between the tests, confirming the levels of agreement reported by Rolak (87%) and Swart and Millac (92%). Abnormal VEPs, however, were more closely associated with cases of clinically definite multiple sclerosis (MS) while abnormal FOCs were more frequent in cases of non-demyelinating disease and cases without clinically evident optic nerve or other ocular disorder. We cannot explain this result by any demonstrated superiority of the FOC test over VEPs in non-demyelinating visual disturbances, whether clinically evident or not. Thus the study does not confirm the earlier expectation that the FOC test would be a reliable alternative to the study of VEPs in the differential diagnosis of MS.
在一项为期两年的前瞻性研究中，对135名患者的色觉漂移（FOC）测试和视觉诱发电位（VEP）进行了比较，以确定FOC测试是否是一种敏感且可靠的替代方法。我们发现这两种测试的总体一致性为80%，证实了罗拉克（87%）以及斯沃特和米拉奇（92%）报告的一致性水平。然而，异常VEP与临床确诊的多发性硬化症（MS）病例关联更为密切，而异常FOC在非脱髓鞘疾病以及无临床明显视神经或其他眼部疾病的病例中更为常见。无论是临床明显的还是不明显的非脱髓鞘视觉障碍，我们都无法通过任何已证实的FOC测试优于VEP的情况来解释这一结果。因此，该研究并未证实早期的预期，即在MS的鉴别诊断中，FOC测试将是研究VEP的可靠替代方法。
