The Walton Centre NHS Foundation Trust, Liverpool, UK, Institute for Infection and Global Health, Liverpool, UK and NIHR Health Protection Research Unit for Emerging and Zoonotic Infection at University of Liverpool, Liverpool, UK.
Institute for Infection and Global Health, Liverpool, UK.
Clin Med (Lond). 2020 Jul;20(4):389-392. doi: 10.7861/clinmed.2020-0241.
In recent years, autoimmunity has been increasingly recognised as an important cause of encephalitis. Many different antibodies are now known to target antigens on the neuronal surface, and some of these are associated with characteristic clinical presentations, although seronegative cases are also recognised. Autoimmune encephalitis may mimic other conditions, including primary psychiatric disorders, particularly early in the disease. Because early immune treatment of autoimmune encephalitis improves patient outcomes, and indeed many make a good recovery, it is important to recognise these syndromes promptly.
近年来,自身免疫已被越来越多地认为是脑炎的一个重要病因。现在已知许多不同的抗体针对神经元表面的抗原,其中一些与特征性的临床表现相关,尽管也有血清阴性病例。自身免疫性脑炎可能模仿其他病症,包括原发性精神障碍,尤其是在疾病早期。由于早期免疫治疗自身免疫性脑炎可改善患者的预后,而且事实上许多患者都能很好地恢复,因此迅速识别这些综合征非常重要。