Zhang Guo-Fang, Liang Tao, Lv Yi-Kun, Luo Zhong, Zhang Jun
Department of Neurology Affiliated Hospital of Zunyi Medical University Zunyi China.
Ibrain. 2023 Jun 25;10(3):378-384. doi: 10.1002/ibra.12116. eCollection 2024 Fall.
Autoimmune encephalitis (AE) is an autoimmune disease in the central nervous system. Clinical manifestations include cognitive dysfunction, psychiatric-behavioral abnormalities, epilepsy, motor disorders, speech disorders, and memory impairment. Some patients do not have the characteristic clinical manifestations of the disease when they see a doctor, so they are easily diagnosed incorrectly. Autoimmune antibodies originate from genetic and acquired factors. Clinical data have found a correlation between ovarian teratoma and autoimmune encephalitis. This case reports a 34-year-old woman who was diagnosed with teratoma-associated anti-N-methyl-D- aspartate receptor-mediated autoimmune encephalitis called anti-N-methyl-D-aspartate receptor encephalitis with bilateral hearing loss in 2021. Through this case report, clinicians will pay attention to autoimmune encephalitis and raise awareness of the specific clinical manifestations of autoimmune encephalitis, and focus on early identification. It means that clinicians should be familiar with the representative clinical manifestations of the disease.
自身免疫性脑炎（AE）是一种中枢神经系统的自身免疫性疾病。临床表现包括认知功能障碍、精神行为异常、癫痫、运动障碍、言语障碍和记忆损害。部分患者就诊时无该病的特征性临床表现，故易被误诊。自身免疫抗体源于遗传和后天因素。临床资料发现卵巢畸胎瘤与自身免疫性脑炎之间存在关联。本病例报告了一名34岁女性，她于2021年被诊断为畸胎瘤相关的抗N-甲基-D-天冬氨酸受体介导的自身免疫性脑炎，即抗N-甲基-D-天冬氨酸受体脑炎，伴有双侧听力丧失。通过本病例报告，临床医生将关注自身免疫性脑炎，提高对自身免疫性脑炎特定临床表现的认识，并注重早期识别。这意味着临床医生应熟悉该病的典型临床表现。
