Division of Upper GI and Thoracic Surgery, McGill University Health Centre, Montral, QC, Canada.
Department of Surgery, University of Pittsburgh Medical Center, Hermitage, PA.
Ann Surg. 2020 Aug;272(2):277-283. doi: 10.1097/SLA.0000000000003586.
: Since their discovery, neutrophil extracellular traps (NETs) have been implicated in a broad array of functions, both beneficial and detrimental to the host. Indeed, NETs have roles in infection, sepsis, wound healing, thrombotic disease, and cancer propagation, all of which are directly implicated in the care of surgical patients. Here we provide an updated review on the role of NETs in the perioperative period with specific emphasis on perioperative infections, wound healing, vascular complications, cancer propagation, as well as discussing ongoing, and future therapeutic targets. Surgeons will benefit from understanding the latest discoveries in neutrophil biology and how these novel functions affect the care of surgical patients. Furthermore, novel anti-NET therapies are being developed which may have profound effects on the care of surgical patients.
: 自发现以来，中性粒细胞胞外陷阱（NETs）已被牵涉到广泛的功能中，既有对宿主有益的，也有有害的。事实上，NETs 在感染、败血症、伤口愈合、血栓性疾病和癌症传播中发挥作用，所有这些都直接与外科患者的护理有关。在这里，我们提供了一个关于 NETs 在围手术期作用的最新综述，特别强调围手术期感染、伤口愈合、血管并发症、癌症传播，并讨论正在进行的和未来的治疗靶点。外科医生将受益于了解中性粒细胞生物学的最新发现，以及这些新功能如何影响外科患者的护理。此外，正在开发新型的抗 NET 疗法，这可能对外科患者的护理产生深远影响。
