Division of Inflammation Biology, Institute of Enzyme Research, Tokushima University, Tokushima, Japan.
Cell Tissue Res. 2018 Mar;371(3):531-539. doi: 10.1007/s00441-017-2785-7. Epub 2018 Jan 30.
As one of the first defenders of innate immune response, neutrophils make a rapid and robust response against infection or harmful agents. While traditionally regarded as suicidal killers that cause collateral tissue damage, recent findings on neutrophil extracellular trap formation, heterogeneity and plasticity and novel reparative functions have expanded our understanding of their diverse roles in health and disease. This review summarizes our current understanding of neutrophil-associated tissue injury, highlighting the emerging roles of neutrophil extracellular traps. This review will also focus on scrutinizing the roles of neutrophils in tissue repair and regeneration and will examine data on unexpected aspects of involvement of neutrophils in regulating normal tissue homeostasis.
作为先天免疫反应的第一道防线之一，中性粒细胞对感染或有害因子迅速做出强烈反应。尽管传统上认为中性粒细胞是导致附带组织损伤的自杀性杀伤细胞，但关于中性粒细胞胞外诱捕网形成、异质性和可塑性以及新的修复功能的最新发现，扩展了我们对其在健康和疾病中的多种作用的理解。本综述总结了我们目前对中性粒细胞相关组织损伤的认识，强调了中性粒细胞胞外诱捕网的新兴作用。本综述还将重点探讨中性粒细胞在组织修复和再生中的作用，并研究中性粒细胞在调节正常组织稳态方面的意外作用的数据。
