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胸腔镜治疗伴有远端气管食管瘘(C 型)的食管闭锁:系统评价。

Thoracoscopic Repair of Esophageal Atresia With Distal Tracheoesophageal Fistula (Type C): Systematic Review.

机构信息

Department of Pediatric Surgery, Chelsea Children's Hospital, Chelsea and Westminster Hospital NHS Foundation Trust, Imperial College London, London, UK.

出版信息

Surg Laparosc Endosc Percutan Tech. 2020 Aug;30(4):388-393. doi: 10.1097/SLE.0000000000000832.

Abstract

AIM

This systematic review analyzed outcomes in thoracoscopic "primary" repair of type-C esophageal atresia.

MATERIALS AND METHODS

The Healthcare Database Advance Search, Embase, Medline, and Cochrane databases in accordance with Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines were researched by 2 independent reviewers. Non-English, mixed procedures (open/thoracoscopic) and staged-repair articles were excluded.

RESULTS

Between 2000 and 2018, 173 articles were identified of which 14 met the inclusion criteria and 382 neonates analyzed. Lowest reported age and weight were 28 gestational weeks and 830 g, respectively (gestational weeks: 28 to 41 wk; birth weight: 830 to 3960 g), with 136/382 (36%) having associated comorbidities. All procedures were performed in Cuschieri modified decubitus position with 3 ports (3.5 to 5 mm) and 30-degree scopes. Azygos vein sparing approach was reported in 4/14 (28.5%) articles; and if divided 70% preferred sealing/diathermy devices. Preferences for fistula ligation were sutures in 5/13 (38%) articles, clips or hemlock in 4/13 (30.7%), sutures with clips in 4/13 (30.7%) and no data in 1/14. Transanastomotic tubes placement was reported in 9/14 articles (others no data). Chest tube placement was preferred in 9/12 (75%) articles; 3/12 no chest tubes; and 2/14 no data. Intraoperative complications were reported in 9/382 (2.3%) neonates-respiratory instability (5/9), endoclip displacement (2/9), and anastomotic leak requiring conversion (2/9). Conversion to open thoracotomy was reported in 12/14 articles in 37/382 (9.6%) neonates. Postoperative complications were reported in 94/382 (25%); 79/94 (84%) anastomotic strictures, 40/94 (42.5%) anastomotic leaks and 5/94 (5.3%) recurrent fistulation. There were 17/382 (4.4%) lethal outcomes (cardiopulmonary failure, sepsis, and 1 intraoperative tracheal rupture).

CONCLUSIONS

Thoracoscopic "primary" repair of type-C esophageal atresia is feasible in premature/term neonates with a 1:10 conversion rate. Around one third surgeons prefer azygous sparing approach and three fourth placement of chest tubes, but there is no unanimity on the fistula ligation technique. The procedure has morbidity in one fourth patients and 5% mortality.

摘要

目的

本系统评价分析了胸腔镜“原发性”C 型食管闭锁修复术的结果。

材料和方法

两名独立审查员按照系统评价和荟萃分析的首选报告项目 (PRISMA) 指南,对 Healthcare Database Advance Search、Embase、Medline 和 Cochrane 数据库进行了研究。排除非英语、混合程序(开放/胸腔镜)和分期修复文章。

结果

2000 年至 2018 年期间,共确定了 173 篇文章,其中 14 篇符合纳入标准,分析了 382 例新生儿。报告的最低胎龄和体重分别为 28 孕周和 830g(胎龄:28 至 41 周;出生体重:830 至 3960g),其中 136/382(36%)有合并症。所有手术均在 Cuschieri 改良侧卧位下进行,采用 3 个端口(3.5 至 5mm)和 30 度镜。4/14(28.5%)的文章报道了奇静脉保留术;如果奇静脉被分离,70%的人更倾向于使用密封/电烙设备。在 5/13(38%)的文章中首选缝合线结扎瘘管,在 4/13(30.7%)的文章中首选夹或铁杉,在 4/13(30.7%)的文章中首选缝合线加夹,在 1/14(7.1%)的文章中无数据。在 9/14(64.3%)的文章中报告了经吻合口置管术,其他文章无数据。9/12(75%)的文章中首选放置胸腔引流管;3/12 无胸腔引流管;14/14 无数据。在 382 例新生儿中有 9/382(2.3%)发生术中并发症-呼吸不稳定(5/9)、Endoclip 移位(2/9)和需要转为开放手术的吻合口漏(2/9)。在 14 篇文章中有 12/382(3.1%)的新生儿转为开胸手术。在 382 例新生儿中有 94/382(25%)出现术后并发症;79/94(84%)吻合口狭窄,40/94(42.5%)吻合口漏和 5/94(5.3%)再次出现瘘管。有 17/382(4.4%)致命结局(心肺衰竭、败血症和 1 例术中气管破裂)。

结论

胸腔镜“原发性”C 型食管闭锁修复术在早产儿/足月儿中是可行的,转化率为 1:10。约三分之一的外科医生更喜欢奇静脉保留术和四分之三的胸腔引流管放置,但在瘘管结扎技术上没有共识。该手术使四分之一的患者出现并发症,5%的患者死亡。

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