Department of Medical Oncology, Hospital Universitario Central de Asturias, ISPA, University of Pais Vasco, Pais Vasco, Avenida Roma sn, 33011, Oviedo, Spain.
Department of Clinical Psychology and Psychobiology, Faculty of Psychology, University of Barcelona, University of Pais Vasco, Pais Vasco, Barcelona, Spain.
Clin Transl Oncol. 2021 Mar;23(3):657-662. doi: 10.1007/s12094-020-02454-z. Epub 2020 Jul 16.
To identify distinct trajectories of toxicity in colorectal cancer (CRC) patients after adjuvant chemotherapy and its impact on quality of life (QoL) and psychological symptoms.
A prospective, multicenter study was conducted in 157 patients. A latent class analysis defined the unobserved latent constructs that can be predicted as symptom clusters, considering the intensity of four types of adverse events (AEs). Patients completed EORTC-QLQ-C30, BSI-18, PDRQ-9, and DRS scales.
Ninety-six percent had some degree of toxicity, with grades 3-4 being the most common: neurotoxicity (7.2%), hematological (13.1%), digestive (5.2%), and skin toxicity (1.4%). Three distinct latent classes were identified (high [72.5%], mild [16.9%], and low [10.6%] toxicity). Patients with high toxicity had the worst QoL scores and moderately high somatization and psychological distress scores.
Adjuvant chemotherapy for CRC was associated with frequent toxicity that negatively impacted QoL and psychological wellbeing.
鉴定结直肠癌（CRC）患者辅助化疗后毒性的不同轨迹及其对生活质量（QoL）和心理症状的影响。
在 157 名患者中进行了一项前瞻性、多中心研究。潜在类别分析定义了不可观察的潜在结构，可以将其预测为症状群，考虑到四种类型的不良事件（AEs）的强度。患者完成 EORTC-QLQ-C30、BSI-18、PDRQ-9 和 DRS 量表。
96%的患者有一定程度的毒性，最常见的是 3-4 级：神经毒性（7.2%）、血液学毒性（13.1%）、消化系统毒性（5.2%）和皮肤毒性（1.4%）。确定了三个不同的潜在类别（高[72.5%]、轻度[16.9%]和低[10.6%]毒性）。毒性较高的患者 QoL 评分最差，躯体化和心理困扰评分中度较高。
CRC 的辅助化疗与频繁的毒性有关，这些毒性对 QoL 和心理健康有负面影响。
