蓝蝎毒液（Rhopalurus junceus）对神经胶质瘤细胞系模型的细胞毒性作用。
Cytotoxic Effects of Blue Scorpion Venom (Rhopalurus junceus) in a Glioblastoma Cell Line Model.
机构信息
Departamento de Biologia, Facultad de Ciencias, Universidad del Tolima, 730006299, Ibague, Colombia.
Departamento de Ciencias Clinicas, Facultad de Ciencias de la Salud, Universidad del Tolima, 730006299, Ibague, Colombia.
出版信息
Curr Pharm Biotechnol. 2021;22(5):636-645. doi: 10.2174/1389201021666200717092207.
BACKGROUND
Cancer is one of the leading cause of death worldwide. Besides current therapies and treatments to counter cancer, new alternatives are required to diminish the cell proliferation of oncogenic processes.
METHODS
One of the most promissory therapy includes the use of blue scorpion venom as a specific cytotoxic agent to kill tumoral cells, including Glioblastoma multiforme.
OBJECTIVES
We show evidence of the cytotoxic effect of blue scorpion venom in a cellular model of Glioblastoma multiforme.
RESULTS
Our results demonstrate that 50 μg/ml of scorpion venom is capable to diminish the viability of Glioblastoma populations.
CONCLUSION
It is possible that the action mechanism could be associated with a loss of membrane integrity. Additionally, some metalloproteinases as MMP2 and MMP9 may also participate in the potential action mechanism.
背景
癌症是全球主要死因之一。除了目前对抗癌症的疗法和治疗方法外，还需要新的替代方法来抑制致癌过程的细胞增殖。
方法
最有前途的治疗方法之一是使用蓝蝎子毒液作为一种特异性细胞毒性剂来杀死肿瘤细胞，包括多形性胶质母细胞瘤。
目的
我们在多形性胶质母细胞瘤的细胞模型中证明了蓝蝎子毒液的细胞毒性作用。
结果
我们的结果表明，50μg/ml 的蝎子毒液能够降低胶质母细胞瘤群体的活力。
结论
作用机制可能与膜完整性的丧失有关。此外，一些金属蛋白酶如 MMP2 和 MMP9 也可能参与潜在的作用机制。
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