Sofou Stavroula
Polytechnic University, Laboratory for Drug Delivery Systems, Othmer-Jacobs Department of Chemical and Biological Engineering, Brooklyn, NY, USA.
Nanomedicine (Lond). 2007 Oct;2(5):711-24. doi: 10.2217/17435889.2.5.711.
An overview of liposome-based drug-delivery carriers to cancer cells is presented. Properties related to interfacial interactions between liposomes and the biological milieu that determine the fate of liposomes in vivo are discussed. Original approaches to improve specificity for the target and to control the structural responsiveness of liposomes, depending on their immediate environment, with the aim of enhancing the delivered therapeutic doses, are summarized. This review is not exhaustive on research examples of liposomes as carriers for cancer therapy but, rather, aims to describe major directions of designs and strategies over recent years. The current therapeutic trends that exhibit increasingly higher complexity in structures and responses are also discussed.
本文概述了基于脂质体的癌细胞药物递送载体。讨论了与脂质体和生物环境之间的界面相互作用相关的性质，这些性质决定了脂质体在体内的命运。总结了一些原始方法，这些方法旨在提高对靶点的特异性，并根据脂质体的即时环境控制其结构响应性，以增加递送的治疗剂量。本综述并非详尽无遗地列举脂质体作为癌症治疗载体的研究实例，而是旨在描述近年来设计和策略的主要方向。还讨论了目前在结构和反应方面表现出越来越高复杂性的治疗趋势。
