近年来用于乳腺癌治疗的脂质体制剂的新进展。
Recent advances in liposome formulations for breast cancer therapeutics.
机构信息
ARC Centre of Excellence for Nanoscale Biophotonics, the Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW, 2052, Australia.
School of Mechatronic Engineering, University of New South Wales, Sydney, NSW, 2052, Australia.
出版信息
Cell Mol Life Sci. 2021 Jul;78(13):5225-5243. doi: 10.1007/s00018-021-03850-6. Epub 2021 May 11.
Abstract
Among many nanoparticle-based delivery platforms, liposomes have been particularly successful with many formulations passed into clinical applications. They are well-established and effective gene and/or drug delivery systems, widely used in cancer therapy including breast cancer. In this review we discuss liposome design with the targeting feature and triggering functions. We also summarise the recent progress (since 2014) in liposome-based therapeutics for breast cancer including chemotherapy and gene therapy. We finally identify some challenges on the liposome technology development for the future clinical translation.
摘要
在众多基于纳米粒子的递药系统中，脂质体取得了特别的成功，有许多制剂已进入临床应用。脂质体是一种成熟且有效的基因和/或药物递药系统，广泛用于癌症治疗，包括乳腺癌。在本文中，我们讨论了具有靶向特征和触发功能的脂质体设计。我们还总结了自 2014 年以来基于脂质体的乳腺癌治疗（包括化疗和基因治疗）的最新进展。最后，我们确定了脂质体技术未来临床转化所面临的一些挑战。
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2
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