The Department of Food Science and Nutrition, Dong-A University, Busan 49315, Republic of Korea; The Center for Silver-Targeted Biomaterials, Brain Busan 21 Plus Program, Graduate School, Dong-A University, Busan 49315, Republic of Korea.
The Department of Anatomy, Chonnam National University, Chonnam National University Medical School, Hwasun 58128, Jeollanam-do, Republic of Korea.
Pharmacol Res. 2020 Oct;160:105083. doi: 10.1016/j.phrs.2020.105083. Epub 2020 Jul 15.
Diabetes-induced dementia is an emerging neurodisorder all over the world. The prevalence rates of dementia and diabetes have been gradually increasing worldwide. Diabetes has been known to lead to oxidative stress, inflammation aggravation, and hyperglycemia conditions in the brain. Various diabetic implications cause the lower secretion of brain-derived neurotrophic factor (BDNF) and the increase of receptor for advanced glycation end products (RAGE), ultimately leading to both cerebrovascular dysfunction and cognitive decline. Here, we summarized the significant evidences highlighting the specific mechanisms between BDNF and RAGE and cerebrovascular dysfunction and memory function and how these relate to diabetes-induced dementia. Especially, we review that the association between BDFN and RAGE in neuroinflammation, the reduction of long-term potentiation, and the vascular implications in brain.
糖尿病性痴呆是一种在全球范围内新兴的神经紊乱疾病。全球范围内痴呆症和糖尿病的患病率一直在逐渐增加。众所周知，糖尿病会导致大脑中的氧化应激、炎症加重和高血糖状态。各种糖尿病的影响导致脑源性神经营养因子 (BDNF) 的分泌减少和晚期糖基化终产物受体 (RAGE) 的增加，最终导致脑血管功能障碍和认知能力下降。在这里，我们总结了强调 BDNF 和 RAGE 与脑血管功能障碍和记忆功能之间特定机制的重要证据，以及它们与糖尿病性痴呆的关系。特别是，我们回顾了神经炎症中 BDFN 和 RAGE 之间的关联、长时程增强的减少以及大脑中的血管影响。
