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从探索蜂胶成分的化学空间和化学多样性中获得的启示。

Lessons from Exploring Chemical Space and Chemical Diversity of Propolis Components.

机构信息

GeneCology Research Centre, School of Science and Engineering, University of the Sunshine Coast, Maroochydore DC, Queensland 4558, Australia.

Department of Pharmacy, School of Chemistry, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.

出版信息

Int J Mol Sci. 2020 Jul 15;21(14):4988. doi: 10.3390/ijms21144988.

DOI:10.3390/ijms21144988
PMID:32679731
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7404124/
Abstract

Propolis is a natural resinous material produced by bees and has been used in folk medicines since ancient times. Due to it possessing a broad spectrum of biological activities, it has gained significant scientific and commercial interest over the last two decades. As a result of searching 122 publications reported up to the end of 2019, we assembled a unique compound database consisting of 578 components isolated from both honey bee propolis and stingless bee propolis, and analyzed the chemical space and chemical diversity of these compounds. The results demonstrated that both honey bee propolis and stingless bee propolis are valuable sources for pharmaceutical and nutraceutical development.

摘要

蜂胶是蜜蜂产生的一种天然树脂材料，自古以来就被用于民间药物。由于它具有广泛的生物活性，在过去的二十年中，它引起了科学界和商业界的极大兴趣。通过搜索截至 2019 年底报告的 122 篇出版物，我们组装了一个独特的化合物数据库，其中包含 578 种从蜜蜂蜂胶和无刺蜂蜂胶中分离得到的成分，并分析了这些化合物的化学空间和化学多样性。结果表明，蜜蜂蜂胶和无刺蜂蜂胶都是药物和营养保健品开发的有价值的来源。

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