Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine LMU Munich, Veterinaerstrasse 13, Munich 80539, Germany.
Clinical Laboratory, Department for Clinical Diagnostics and Services, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, Zurich 8057, Switzerland.
Vet Clin North Am Small Anim Pract. 2020 Sep;50(5):1013-1036. doi: 10.1016/j.cvsm.2020.05.006. Epub 2020 Jul 14.
Feline leukemia virus (FeLV) is a retrovirus with global impact on the health of domestic cats that causes tumors (mainly lymphoma), bone marrow disorders, and immunosuppression. The importance of FeLV is underestimated due to complacency associated with previous decline in prevalence. However, with this comes lowered vigilance, which, along with potential for regressively infected cats to reactivate viremia and shed the virus or develop clinical signs, can pose a risk to feline health. This article summarizes knowledge on FeLV pathogenesis, courses of infection, and factors affecting prevalance, infection outcome, and development of FeLV-associated diseases, with special focus on regressive FeLV infection.
猫白血病病毒（FeLV）是一种具有全球影响力的逆转录病毒，会导致家猫的肿瘤（主要是淋巴瘤）、骨髓疾病和免疫抑制。由于以前流行率下降带来的自满情绪，FeLV 的重要性被低估了。然而，随之而来的是警惕性降低，再加上退行性感染的猫可能会重新激活病毒血症并排出病毒或出现临床症状，这可能对猫的健康构成威胁。本文总结了 FeLV 发病机制、感染过程以及影响流行率、感染结果和 FeLV 相关疾病发展的因素的知识，特别关注退行性 FeLV 感染。
