淋巴瘤猫持续性病毒血症和潜伏性猫白血病病毒感染的发生率。
Incidence of persistent viraemia and latent feline leukaemia virus infection in cats with lymphoma.
作者信息
Stützer Bianca, Simon Karin, Lutz Hans, Majzoub Monir, Hermanns Walter, Hirschberger Johannes, Sauter-Louis Carola, Hartmann Katrin
机构信息
Clinic of Small Animal Medicine, LMU University of Munich, Veterinaerstrasse 13, Munich, Germany.
出版信息
J Feline Med Surg. 2011 Feb;13(2):81-7. doi: 10.1016/j.jfms.2010.09.015. Epub 2010 Dec 4.
In the past, feline leukaemia virus (FeLV) infection, and also latent FeLV infection, were commonly associated with lymphoma and leukaemia. In this study, the prevalence of FeLV provirus in tumour tissue and bone marrow in FeLV antigen-negative cats with these tumours was assessed. Seventy-seven diseased cats were surveyed (61 antigen-negative, 16 antigen-positive). Blood, bone marrow, and tumour samples were investigated by two polymerase chain reaction (PCR) assays detecting deoxyribonucleic acid (DNA) sequences of the long terminal repeats (LTR) and the envelope (env) region of the FeLV genome. Immunohistochemistry (IHC) was performed in bone marrow and tumour tissue. None of the antigen-negative cats with lymphoma was detectably infected with latent FeLV. The prevalence of FeLV viraemia in cats with lymphoma was 20.8%. This suggests that causes other than FeLV play a role in tumorigenesis, and that latent FeLV infection is unlikely to be responsible for most feline lymphomas and leukaemias.
过去，猫白血病病毒（FeLV）感染以及潜伏性FeLV感染通常与淋巴瘤和白血病有关。在本研究中，评估了患有这些肿瘤的FeLV抗原阴性猫的肿瘤组织和骨髓中FeLV前病毒的流行情况。对77只患病猫进行了调查（61只抗原阴性，16只抗原阳性）。通过两种聚合酶链反应（PCR）检测法对血液、骨髓和肿瘤样本进行了检测，这两种检测法可检测FeLV基因组的长末端重复序列（LTR）和包膜（env）区域的脱氧核糖核酸（DNA）序列。在骨髓和肿瘤组织中进行了免疫组织化学（IHC）检测。患有淋巴瘤的抗原阴性猫均未被检测出潜伏性FeLV感染。患有淋巴瘤的猫中FeLV病毒血症的流行率为20.8%。这表明除FeLV外的其他因素在肿瘤发生中起作用，并且潜伏性FeLV感染不太可能是大多数猫淋巴瘤和白血病的病因。
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