健康老年人静息态阿尔法节律与血氧水平依赖信号的关系改变：基于 EEG-fMRI 融合分析的证据。
Altered relation of resting-state alpha rhythm with blood oxygen level dependent signal in healthy aging: Evidence by EEG-fMRI fusion analysis.
机构信息
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China; National Engineering Research Center for Healthcare Devices, Guangzhou, China.
Department of Radiology, Henan Provincial People's Hospital, Zhengzhou, China.
出版信息
Clin Neurophysiol. 2020 Sep;131(9):2105-2114. doi: 10.1016/j.clinph.2020.05.025. Epub 2020 Jun 18.
OBJECTIVE
The goal of this study is to explore the changes of spatial correlates of alpha rhythm in the aged adults.
METHODS
Electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) data were simultaneously recorded from 27 young and 19 elderly adults at resting state with their eyes closed. Alpha rhythm power fluctuation was extracted from EEG signal of parietal-occipital region and was fused with fMRI data by correlating alpha rhythm with blood oxygen level dependent (BOLD) signal using general linear models.
RESULTS
For both young adults and the elderly, the regions correlated with alpha rhythm power were widely distributed in cortical and subcortical regions. However, compared to young adults, correlations between alpha rhythm and the activity of thalamus and frontal regions were significantly reduced in the elderly. In addition, an increased correlation with alpha rhythm was found in frontal, insula and cingulate gyrus regions in the elderly.
CONCLUSIONS
Changes in the roles of the above brain regions may be present in the generation or modulation of alpha rhythm due to age advancing.
SIGNIFICANCE
This study provides novel insight into the alteration of the spatial correlates of alpha rhythm in the elderly by using simultaneous EEG-fMRI data fusion analysis.
目的
本研究旨在探讨老年人 alpha 节律空间相关变化。
方法
对 27 名年轻成年人和 19 名老年成年人进行静息状态下的脑电图（EEG）和功能磁共振成像（fMRI）同步记录，记录时要求被试闭眼。从顶枕部的 EEG 信号中提取 alpha 节律功率波动，并通过使用广义线性模型将 alpha 节律与血氧水平依赖（BOLD）信号相关联，将 alpha 节律与 fMRI 数据融合。
结果
对于年轻成年人和老年人，与 alpha 节律功率相关的区域广泛分布于皮质和皮质下区域。然而，与年轻成年人相比，老年人的丘脑和额叶区域的 alpha 节律与活动之间的相关性显著降低。此外，在老年人中还发现额叶、脑岛和扣带回区域与 alpha 节律的相关性增加。
结论
由于年龄的增长，上述脑区在 alpha 节律的产生或调制中可能发挥不同的作用。
意义
本研究通过同步 EEG-fMRI 数据融合分析，为理解老年人 alpha 节律空间相关变化提供了新的视角。
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