Department of Immunology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran; Immunology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Department of Immunology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran; Immunology Research Center, Iran University of Medical Sciences, Tehran, Iran; Student Research Committee, Iran University of Medical Sciences, Tehran, Iran.
Int Immunopharmacol. 2020 Oct;87:106776. doi: 10.1016/j.intimp.2020.106776. Epub 2020 Jul 15.
During pregnancy, the fetal-maternal interface underlies several dynamic alterations to permit the fetus to be cultivated and developed in the uterus, in spite of being identifies by the maternal immune system. A large variety of decidual leukocyte populations, including natural killer cells, NKT cells, innate lymphoid cells, dendritic cells, B cells, T cells, subpopulations of helper T cells play a vital role in controlling the trophoblast invasion, angiogenesis as well as vascular remodeling. In contrast, several regulatory immunosuppressive mechanisms, including regulatory T cells, regulatory B cells, several cytokines and mediators are involved in maintain the homeostasis of immune system in the fetal-maternal interface. Nonetheless, aberrant alterations in the balance of immune inflammatory or immunosuppressive arms have been associated with various pregnancy losses and infertilities. As a result, numerous strategies have been developed to revers dysregulated balance of immune players to increase the chance of successful pregnancy. Lymphocyte immunotherapy has been developed through utilization of peripheral white blood cells of the husband or others and administered into the mother to confer an immune tolerance for embryo's antigens. However, the results have not always been promising, implying to further investigations to improve the approach. This review attempts to clarify the involvement of lymphocytes in contributing to the pregnancy outcome and the potential of lymphocyte immunotherapy in treatment of infertilities with dysregulated immune system basis.
在妊娠期间，胎儿-母体界面发生了多种动态变化，以使胎儿能够在子宫内得到培养和发育，尽管它被母体免疫系统识别。大量的蜕膜白细胞群体，包括自然杀伤细胞、NKT 细胞、固有淋巴细胞、树突状细胞、B 细胞、T 细胞、辅助 T 细胞亚群，在控制滋养层浸润、血管生成和血管重塑方面发挥着重要作用。相比之下，几种调节性免疫抑制机制，包括调节性 T 细胞、调节性 B 细胞、几种细胞因子和介质，参与维持胎儿-母体界面免疫系统的稳态。然而，免疫炎症或免疫抑制机制失衡的异常改变与各种妊娠丢失和不孕有关。因此，已经开发了许多策略来逆转免疫参与者的失调平衡，以增加成功妊娠的机会。淋巴细胞免疫疗法是通过利用丈夫或其他人的外周白细胞，并将其注入母亲体内，使母亲对胚胎抗原产生免疫耐受。然而，结果并不总是令人满意，这意味着需要进一步的研究来改进这种方法。本综述试图阐明淋巴细胞在妊娠结局中的作用以及淋巴细胞免疫疗法在治疗基于免疫系统失调的不孕中的潜力。
