帕金森病中炎症因子与衰老的关联。

Association of inflammatory factors and aging in Parkinson's disease.

机构信息

Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.

出版信息

Neurosci Lett. 2020 Sep 25;736:135259. doi: 10.1016/j.neulet.2020.135259. Epub 2020 Jul 16.

DOI:10.1016/j.neulet.2020.135259

PMID:32682845

Abstract

BACKGROUND

Parkinson's disease as a common neurodegenerative disease, has been found to be related to inflammation. So we observed the characteristics of inflammatory indexes in patients with Parkinson's disease and investigated the relationship between inflammatory cytokines and clinical characteristics. Emerging data may reveal novel neuroinflammatory pathways and identify new targets for treatment of Parkinson's disease.

METHODS

We examined the inflammatory indexes in 183 patients and 89 healthy controls in association with clinical characteristics.

RESULTS

Patients had significantly higher levels of monocytes, neutrophils, high-sensitivity C-reactive protein, and monocyte-to-high-density lipoprotein ratios (p < 0.01) and lower levels of lymphocytes (p = 0.02) than the controls. There were no significant differences in age, leukocytes, high-density lipoprotein, or neutrophil-lymphocyte ratios between the two groups (p > 0.05). Multivariate logistic regression analysis of these indicators revealed that lymphocyte level was a protective factor (p = 0.025, OR=-0.679), while high-sensitivity C-reactive protein level was a risk factor (p = 0.000, OR=1.168) for Parkinson's disease. High-sensitivity C-reactive protein levels were higher in older Parkinson's disease patients.

CONCLUSION

High-sensitivity C-reactive protein is positively related to the risk of Parkinson's disease, especially in aging patients. High-sensitivity C-reactive protein is a potential biomarker for disease progression and treatment response for Parkinson's disease.

摘要

背景

帕金森病作为一种常见的神经退行性疾病，已被发现与炎症有关。因此，我们观察了帕金森病患者的炎症指标特征，并研究了炎症细胞因子与临床特征之间的关系。新出现的数据可能揭示新的神经炎症途径，并为帕金森病的治疗确定新的靶点。

方法

我们检查了 183 名患者和 89 名健康对照者的炎症指标，并与临床特征相关联。

结果

与对照组相比，患者的单核细胞、中性粒细胞、高敏 C 反应蛋白和单核细胞/高密度脂蛋白比值显著升高（p<0.01），而淋巴细胞水平显著降低（p=0.02）。两组间年龄、白细胞、高密度脂蛋白或中性粒细胞/淋巴细胞比值无显著差异（p>0.05）。对这些指标进行多变量逻辑回归分析显示，淋巴细胞水平是保护因素（p=0.025，OR=-0.679），而高敏 C 反应蛋白水平是帕金森病的危险因素（p=0.000，OR=1.168）。老年帕金森病患者的高敏 C 反应蛋白水平更高。