Aktaş Karabay Ezgi, Demir Damla, Aksu Çerman Aslı
Department of Dermatology and Venereology, Faculty of Medicine, Bahçeşehir University, İstanbul, Turkey.
Department of Dermatology and Venereology, Sisli Hamidiye Etfal Training and Research Hospital, Health Sciences University, Istanbul, Turkey.
An Bras Dermatol. 2020 Jan-Feb;95(1):40-45. doi: 10.1016/j.abd.2019.05.002. Epub 2019 Dec 9.
Psoriasis is a chronic immune-mediated inflammatory skin disease that is associated with cardiovascular comorbidities.
The objective of this retrospective study is to assess the C-reactive protein, monocyte-to-high-density-lipoprotein ratio, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio as inflammatory markers in patients with psoriasis and to search for a relationship between these parameters and psoriasis severity, as defined by the psoriasis area and severity index.
There were 94 patients with psoriasis and 118 healthy controls enrolled in the study. The C-reactive protein, monocyte-to-high-density-lipoprotein ratio, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio values of two groups were retrospectively evaluated.
Statistically significant differences were observed in terms of C-reactive protein, monocyte-to-high-density-lipoprotein ratio, neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio between the patient and control groups (p=0.001, p=0.003, p=0.038, and p=0.007, respectively). Positive correlations were found between the psoriasis area and severity index and the values of C-reactive protein, monocyte-to-high-density-lipoprotein ratio, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio (r: 0.381; p<0.01, r: 0.203; p<0.05, r: 0.268; p<0.01, r: 0.374; p<0.01, r: 0.294; p<0.01, respectively).
The small sample size and the retrospective design of the study are limitations.
Elevated C-reactive protein, monocyte-to-high-density-lipoprotein ratio, neutrophil-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio were significantly associated with psoriasis. A positive correlation between C-reactive protein and monocyte-to-high-density-lipoprotein ratio leads to the suggestion that monocyte-to-high-density-lipoprotein ratio might be a reliable parameter in psoriasis during the follow-up. The relationship between the diasease and inflammatory parameters might provide early detection of cardiovascular morbidities in psoriasis patients.
银屑病是一种慢性免疫介导的炎症性皮肤病，与心血管合并症相关。
这项回顾性研究的目的是评估银屑病患者中作为炎症标志物的C反应蛋白、单核细胞与高密度脂蛋白比值、中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值以及单核细胞与淋巴细胞比值，并寻找这些参数与银屑病严重程度（由银屑病面积和严重程度指数定义）之间的关系。
本研究纳入了94例银屑病患者和118例健康对照。回顾性评估两组的C反应蛋白、单核细胞与高密度脂蛋白比值、中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值以及单核细胞与淋巴细胞比值。
患者组和对照组在C反应蛋白、单核细胞与高密度脂蛋白比值、中性粒细胞与淋巴细胞比值和单核细胞与淋巴细胞比值方面存在统计学显著差异（分别为p = 0.001、p = 0.003、p = 0.038和p = 0.007）。银屑病面积和严重程度指数与C反应蛋白、单核细胞与高密度脂蛋白比值、中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值以及单核细胞与淋巴细胞比值之间存在正相关（r分别为：0.381；p < 0.01，r：0.203；p < 0.05，r：0.268；p < 0.01，r：0.374；p < 0.01，r：0.294；p < 0.01）。
样本量小和研究的回顾性设计是局限性所在。
C反应蛋白、单核细胞与高密度脂蛋白比值、中性粒细胞与淋巴细胞比值以及单核细胞与淋巴细胞比值升高与银屑病显著相关。C反应蛋白和单核细胞与高密度脂蛋白比值之间的正相关表明，在随访期间单核细胞与高密度脂蛋白比值可能是银屑病的一个可靠参数。该疾病与炎症参数之间的关系可能有助于早期发现银屑病患者的心血管疾病。
