School of Engineering, University College Cork, Cork, Ireland; Department of Chemical Engineering, Autonomous University of Coahuila, Saltillo, Coahuila, Mexico.
Department of Chemical Engineering, Autonomous University of Coahuila, Saltillo, Coahuila, Mexico.
Biotechnol Adv. 2020 Nov 1;43:107601. doi: 10.1016/j.biotechadv.2020.107601. Epub 2020 Jul 17.
There has been an increased interest in replacing synthetic colorants by colorants obtained from natural sources, especially microbial pigments. Monascus pigments have been used as natural colorings and food additives in Asia for centuries but have raised toxicity issues. Recently, Talaromyces/Penicillium species have been recognized as potential strains to produce natural pigments similar to those produced by Monascus species. To date, it has not been published a literature compilation about the research and development activity of Talaromyces/Penicillium pigments. Developing a new bioprocess requires several steps, from an initial concept to a practical and feasible application. Industrial applications of fungal pigments will depend on: (i) characterization of the molecules to assure a safe consumption, (ii) stability of the pigments to the processing conditions required by the products where they will be incorporated, (iii) optimizing process conditions to achieve high yields, iv) implementing an efficient product recovery and (v) scale-up of the bioprocess. The above aspects have been reviewed in detail to evaluate the feasibility of reaching a commercial scale of the pigments produced by Talaromyces/Penicillium. Finally, the biological activities of the pigments and their potential applications are discussed.
人们对用天然来源的着色剂替代合成着色剂越来越感兴趣，特别是微生物色素。红曲色素已在亚洲被用作天然着色剂和食品添加剂数百年，但存在毒性问题。最近，塔宾曲霉/青霉被认为是生产类似于红曲色素的天然色素的潜在菌株。迄今为止，尚未有关于塔宾曲霉/青霉色素的研究和开发活动的文献综述。开发新的生物工艺需要经过几个步骤，从最初的概念到实际可行的应用。真菌色素的工业应用将取决于：（i）对分子进行特征描述以确保安全食用，（ii）色素在产品加工条件下的稳定性，这些产品将包含色素，（iii）优化工艺条件以获得高产量，（iv）实施有效的产品回收，以及（v）生物工艺的放大。已详细审查了上述方面，以评估用塔宾曲霉/青霉生产的色素达到商业规模的可行性。最后，讨论了色素的生物活性及其潜在应用。
