The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Integr Cancer Ther. 2020 Jan-Dec;19:1534735420938450. doi: 10.1177/1534735420938450.
To evaluate the effectiveness and feasibility of Managing Cancer and Living Meaningfully (CALM), which is used to reduce chemotherapy-related cognitive impairment (CRCI), relieve psychological distress, and improve quality of life (QOL) in Chinese breast cancer survivors (BCs). Seventy-four BCs were enrolled in this study. All patients were randomly assigned to either the CALM group or the care as usual (CAU) group. All patients were evaluated by the Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog), Distress Thermometer (DT), and the Functional Assessment of Cancer Therapy-Breast (FACT-B) before and after CALM or CAU application to BCs with CRCI. We compared the differences in all these scores between the CALM group and the control group and analyzed the correlation between cognitive function and QOL. Compared with the CAU group, the performance of the CALM group on the FACT-Cog, DT, and FACT-B showed significant differences before and after CALM ( = -18.909, -5.180, -32.421, = .000, .000, .000, respectively). Finally, there was a positive correlation between cognitive function and QOL in breast cancer patients before ( = 0.579, = .000) and after ( = 0.797, = .000) treatment. The present results indicated that CALM has salutary effects on the improvement of cognitive impairment and QOL and relieves psychological distress in breast cancer patients, which may be due to a positive correlation between psychological distress and cognitive function or QOL.
为了评估用于减轻乳腺癌幸存者（BC）化疗相关认知障碍（CRCI）、缓解心理困扰和提高生活质量（QOL）的管理癌症和有意义地生活（CALM）的有效性和可行性，招募了 74 名 BC 患者。所有患者均被随机分配至 CALM 组或常规护理（CAU）组。所有患者在应用 CALM 或 CAU 前后均通过癌症治疗功能评估-认知功能（FACT-Cog）、痛苦温度计（DT）和癌症治疗功能评估-乳房（FACT-B）进行评估。我们比较了 CALM 组和对照组之间所有这些评分的差异，并分析了认知功能和 QOL 之间的相关性。与 CAU 组相比，CALM 组在应用 CALM 前后的 FACT-Cog、DT 和 FACT-B 上的表现差异均有统计学意义（=-18.909，-5.180，-32.421，=0.000，0.000，0.000，分别）。最后，在治疗前后，乳腺癌患者的认知功能与 QOL 之间均呈正相关（=0.579，=0.000；=0.797，=0.000）。 结果表明，CALM 对改善认知障碍和 QOL 以及缓解乳腺癌患者的心理困扰具有有益作用，这可能是由于心理困扰与认知功能或 QOL 之间存在正相关。
