Department of Veterinary Medicine, Animal Reproduction, Faculty of Veterinary Medicine and Animal Science, Federal University of Mato Grosso do Sul, Campo Grande, Brazil.
Department of Veterinary Medicine, Surgery and Anaesthesiology, Faculty of Veterinary Medicine and Animal Science, Federal University of Mato Grosso do Sul, Campo Grande, Brazil.
J Equine Vet Sci. 2020 Aug;91:103015. doi: 10.1016/j.jevs.2020.103015. Epub 2020 Apr 22.
The objective of the study was to compare the effects of caudal epidural bupivacaine and dexmedetomidine (DEX) combination, with bupivacaine or DEX plain for perineal analgesia in mares. Six healthy saddle mares weighing 330-370 kg and aged 10-15 years were used in this study. Each mare was assigned to receive three treatments: 0.04 mg/kg 0.25% bupivacaine (BP), 2 μg/kg DEX (DX), or 0.02 mg/kg bupivacaine and 1 μg/kg DEX (BPDX). The order of treatments was randomized. All drugs were injected into the caudal epidural space (Co1-Co2) through a 16-G Tuohy epidural needle. After the epidural injections, heart rate, respiratory rate, arterial blood pressures (systolic, diastolic, and mean), and rectal temperature were measured at 5, 10, 15, 30, 60, 90, and 120 minutes, and after this time, every 60 minutes until the end of the experiments. A subjective score system was used to assess analgesia, behavioral and motor blockade at the same time points. The BPDX treatment produced analgesic action with twice the duration (200 minutes) of the BP treatment (97 minutes), but with an analgesic duration shorter than the DX treatment (240 minutes) in the regions of the tail, perineum, and upper hind limbs in mares. All treatments showed mild motor blockade. No behavioral changes were observed in any of the animals. There was hemodynamic stability without significant changes in respiratory rate for all treatments. Epidural analgesia using DEX alone or the combination of DEX and bupivacaine may be an option for painful obstetric and gynecological procedures in mares.
本研究的目的是比较布比卡因和右美托咪定（DEX）复合剂、布比卡因或DEX 单纯制剂用于母马阴部镇痛的效果。本研究使用了 6 匹健康的鞍马，体重 330-370kg，年龄 10-15 岁。每匹马被分配接受三种治疗：0.04mg/kg0.25%布比卡因（BP）、2μg/kgDEX（DX）或 0.02mg/kg 布比卡因和 1μg/kg 右美托咪定（BPDX）。治疗顺序是随机的。所有药物均通过 16-G 号 Tuohy 硬膜外针注入尾侧硬膜外腔（Co1-Co2）。硬膜外注射后，在 5、10、15、30、60、90 和 120 分钟以及此后每 60 分钟测量心率、呼吸率、动脉血压（收缩压、舒张压和平均压）和直肠温度，并同时使用主观评分系统评估镇痛、行为和运动阻滞。BPDX 治疗产生的镇痛作用持续时间是 BP 治疗（97 分钟）的两倍（200 分钟），但在尾部、会阴和上后肢区域的镇痛作用持续时间短于 DX 治疗（240 分钟）。所有治疗均表现出轻度的运动阻滞。所有动物均未观察到行为变化。所有治疗均无呼吸频率显著变化，血流动力学稳定。DEX 单独或与布比卡因联合用于硬膜外镇痛可能是母马产科和妇科疼痛程序的一种选择。
