共轭亚油酸补充剂可保留高脂肪成年人的肌肉：一项双盲、随机、安慰剂对照试验。

Conjugated linoleic acid supplements preserve muscle in high-body-fat adults: A double-blind, randomized, placebo trial.

机构信息

Department of Nutrition and Food Safety, School of Public Health, Xi'an Jiaotong University Health Science Center, 76 West Yanta Road, 710061, Xi'an, Shaanxi, China.

Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, OX3 7LF, UK; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.

出版信息

Nutr Metab Cardiovasc Dis. 2020 Sep 24;30(10):1777-1784. doi: 10.1016/j.numecd.2020.05.029. Epub 2020 Jun 8.

DOI:10.1016/j.numecd.2020.05.029

PMID:32684362

Abstract

BACKGROUND AND AIMS

Conjugated linoleic acid (CLA) has been used to improve body composition in weight management. However, clinical trial results are inconsistent and limited among Asians. We aimed to investigate the effect of CLA on body composition of Chinese adults with elevated body fat percentage.

METHODS AND RESULTS

In this double-blind, randomized, placebo-controlled trial, 66 Chinese adults (aged 18-45 years old, 37.9% male) with elevated body fat percentage were provided with 3.2 g/day CLA (n = 33) or 3.2 g/day placebo (sunflower oil; n = 33) for 12 weeks. Both groups received lifestyle counseling, featured with low fat and low sugar diet, and moderate physical activity. Body composition was measured using dual-energy X-ray absorptiometry at the baseline and end of the trial. Sixty-four participants finished this study. Compared with the placebo group, the CLA group showed increased trunk muscle mass (MM) (0.6 ± 1.7 vs. -0.3 ± 1.2 kg, P = 0.019). Among those with an adherence score higher than 0.80 (n = 56, 87.5%), a greater increase in both total and trunk MM was observed in the CLA group (both P < 0.05). Moreover, the effect on MM appeared to be more evident in men, those with a body mass index <25 kg/m, or those with higher self-rated physical activity.

CONCLUSIONS

In Chinese adults with elevated body fat percentage, 3.2 g/day CLA supplementation may be effective in preserving MM, especially in the trunk region.

REGISTRATION

This study was registered at ClinicalTrials.gov as NCT03915808 on April 9, 2019.

摘要

背景与目的

共轭亚油酸（CLA）已被用于改善体重管理中的身体成分。然而，亚洲人群的临床试验结果并不一致且有限。本研究旨在调查 CLA 对体脂百分比升高的中国成年人身体成分的影响。

方法与结果

在这项双盲、随机、安慰剂对照试验中，我们招募了 66 名体脂百分比升高的中国成年人（年龄 18-45 岁，男性占 37.9%），他们被随机分配至每日摄入 3.2 g CLA 组（n=33）或每日摄入 3.2 g 葵花籽油（安慰剂）组（n=33），共 12 周。两组均接受了低脂肪、低糖饮食和适度体育活动的生活方式指导。在基线和试验结束时，使用双能 X 射线吸收仪测量身体成分。64 名参与者完成了这项研究。与安慰剂组相比，CLA 组的躯干肌肉量（MM）增加（0.6±1.7 与 -0.3±1.2 kg，P=0.019）。在依从性评分高于 0.80（n=56，87.5%）的参与者中，CLA 组的总躯干 MM 增加更为明显（均 P<0.05）。此外，CLA 对 MM 的影响在男性、BMI<25 kg/m2 或自我评估身体活动水平较高的人群中更为明显。