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Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis.与 2019 年冠状病毒病(COVID-19)严重疾病和死亡相关的血液学、生物化学和免疫生物标志物异常:荟萃分析。
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Coronavirus Disease 2019 in Children - United States, February 12-April 2, 2020.2019 年冠状病毒病在儿童中的情况-美国,2020 年 2 月 12 日至 4 月 2 日。
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High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients With Coronavirus Disease 2019.大剂量静脉注射免疫球蛋白作为新型冠状病毒肺炎病情恶化患者的一种治疗选择
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儿童感染严重急性呼吸综合征冠状病毒2

SARS-CoV-2 infection in children.

作者信息

Çokuğraş Haluk, Önal Pınar

机构信息

Division of Pediatric Allergy, Chest Diseases, Infectious Diseases, Department of Pediatrics, İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, İstanbul, Turkey.

Division of Pediatric Infectious Diseases, Department of Pediatrics, İstanbul University-Cerrahpaşa, Cerrahpaşa Medical Faculty, İstanbul, Turkey.

出版信息

Turk Pediatri Ars. 2020 Jun 19;55(2):95-102. doi: 10.14744/TurkPediatriArs.2020.20270. eCollection 2020.

DOI:10.14744/TurkPediatriArs.2020.20270
PMID:32684754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7344135/
Abstract

SARS-CoV-2, a RNA virus that emerged in December 2019 in the city of Wuhan in China and took hold of the whole world, affects children as well as all age groups. In our country, we started to observe the first cases by March 2020. SARS-CoV-2, which is transmitted by droplets and by way of contact with surfaces contaminated by these droplets, is generally transmitted to children from adults through close contact. There is no proven information about other transmission routes such as fecal-oral transmission. Similar to adults, the primary symptoms at presentation include fever, cough, sore throat, malaise, nasal discharge, and rarely, vomiting and diarrhea in children. Although the majority of pediatric patients are asymptomatic or have a mild clinical course, severe cases have been reported in children with underlying chronic diseases. There is currently no specific antiviral treatment against the SARS-CoV-2 virus. Supportive treatment is recommended in children with a mild course, and some treatments are recommended in children with comorbidities or in children who are observed to have a more severe course. Asymptomatic pediatric patients or pediatric patients who have a mild course constitute an important group in terms of transmission of the infection to the advanced age group who carry high risk. Prevention of infection is very important in terms of reducing new cases and alleviating the load on the healthcare system. In order to prevent transmission of SARS-CoV-2, hygienic rules should be pursued in the community, social distancing should be observed, and the family members and contacts of patients who have been diagnosed should be screened and isolated.

摘要

严重急性呼吸综合征冠状病毒2(SARS-CoV-2)是一种于2019年12月在中国武汉市出现并席卷全球的RNA病毒,影响儿童以及所有年龄段的人群。在我国,到2020年3月我们开始观察到首例病例。SARS-CoV-2通过飞沫以及接触被这些飞沫污染的表面进行传播,通常通过密切接触从成人传播给儿童。目前尚无关于粪口传播等其他传播途径的确切信息。与成人相似,儿童发病时的主要症状包括发热、咳嗽、喉咙痛、不适、流鼻涕,儿童很少出现呕吐和腹泻。虽然大多数儿科患者无症状或临床病程较轻,但有潜在慢性疾病的儿童中已报告出现重症病例。目前尚无针对SARS-CoV-2病毒的特异性抗病毒治疗方法。对于病程较轻的儿童,建议采取支持性治疗,对于患有合并症或观察到病程较重的儿童,推荐一些特定治疗。无症状儿科患者或病程较轻的儿科患者在将感染传播给高危老年人群方面构成一个重要群体。就减少新病例和减轻医疗系统负担而言,预防感染非常重要。为防止SARS-CoV-2传播,社区应遵循卫生规则,保持社交距离,对已确诊患者的家庭成员和接触者进行筛查和隔离。