State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & National Institute of Diagnostics and Vaccine Development in Infectious Disease, School of Public Health, Xiamen University, 361102, China.
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.
Theranostics. 2020 Jun 19;10(17):7821-7835. doi: 10.7150/thno.47987. eCollection 2020.
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently become a pandemic. As the sudden emergence and rapid spread of SARS-CoV-2 is endangering global health and the economy, the development of strategies to contain the virus's spread are urgently needed. At present, various diagnostic kits to test for SARS-CoV-2 are available for use to initiate appropriate treatment faster and to limit further spread of the virus. Several drugs have demonstrated activity against SARS-CoV-2 or potential clinical benefits. In addition, institutions and companies worldwide are working tirelessly to develop treatments and vaccines against COVID-19. However, no drug or vaccine has yet been specifically approved for COVID-19. Given the urgency of the outbreak, we focus here on recent advances in the diagnostics, treatment, and vaccine development for SARS-CoV-2 infection, helping to guide strategies to address the current COVID-19 pandemic.
新型冠状病毒病(COVID-19)由严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)引起,最近已成为一种大流行疾病。由于 SARS-CoV-2 的突然出现和迅速传播正在危及全球健康和经济,因此急需制定控制病毒传播的策略。目前,已有多种用于检测 SARS-CoV-2 的诊断试剂盒可用于更快地启动适当的治疗并限制病毒的进一步传播。一些药物已显示出对 SARS-CoV-2 的活性或具有潜在的临床益处。此外,全球各机构和公司正在不懈努力,开发针对 COVID-19 的治疗方法和疫苗。但是,尚无专门针对 COVID-19 的药物或疫苗获得批准。鉴于疫情的紧迫性,我们在这里重点介绍 SARS-CoV-2 感染的诊断、治疗和疫苗开发方面的最新进展,以帮助指导应对当前 COVID-19 大流行的策略。