Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt.
Department of Industrial & Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA.
Nanomedicine (Lond). 2020 Sep;15(21):2085-2102. doi: 10.2217/nnm-2020-0247. Epub 2020 Jul 29.
The COVID-19 pandemic caused by the newly emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) puts the world in an unprecedented crisis, leaving behind huge human losses and deep socioeconomic damages. Due to the lack of specific treatment against SARS-CoV-2, effective vaccines and antiviral agents are urgently needed to properly restrain the COVID-19 pandemic. Repositioned drugs such as remdesivir have revealed a promising clinical efficacy against COVID-19. Interestingly, nanomedicine as a promising therapeutic approach could effectively help win the battle between coronaviruses (CoVs) and host cells. This review discusses the potential therapeutic approaches, in addition to the contribution of nanomedicine against CoVs in the fields of vaccination, diagnosis and therapy.
由新型严重急性呼吸系统综合症冠状病毒 2(SARS-CoV-2)引发的 COVID-19 大流行使世界陷入前所未有的危机,造成巨大的人员伤亡和深远的社会经济损失。由于缺乏针对 SARS-CoV-2 的特定治疗方法,因此急需有效的疫苗和抗病毒药物来适当控制 COVID-19 大流行。瑞德西韦等重新定位药物已显示出对 COVID-19 的有前景的临床疗效。有趣的是,纳米医学作为一种很有前途的治疗方法,可以有效地帮助赢得冠状病毒(CoVs)与宿主细胞之间的战斗。本文综述了除纳米医学在疫苗接种、诊断和治疗领域对抗 CoVs 的贡献外,还讨论了针对 CoVs 的潜在治疗方法。