Finegan Amber, Mabrouk Usama, Nelson Leigh Anne
PGY2 Psychiatric Pharmacy Resident, Center for Behavioral Medicine, Kansas City, Missouri.
Psychiatrist, Truman Medical Center, Kansas City, Missouri.
Ment Health Clin. 2020 Jul 2;10(4):250-253. doi: 10.9740/mhc.2020.07.250. eCollection 2020 Jul.
Gabapentin binds to the alpha-2-delta subunit of presynaptic voltage-gated calcium channels and is used for a wide variety of on- and off-label indications. Gabapentin is dosed at total daily doses ranging from 300 to 3600 mg/d, which is generally divided into 3 doses. Although gabapentin is generally well tolerated, 1 potential reported adverse effect is peripheral edema. However, due to the extensive number of etiologies of peripheral edema, medication causes may be overlooked on an inpatient psychiatric unit. This is a case of delayed identification of a probable adverse drug reaction to gabapentin (Naranjo score of 5) consisting of painful, 4+ pitting bilateral edema and a clear dose relationship in a patient with pervasive developmental disorder and schizoaffective disorder.
加巴喷丁与突触前电压门控钙通道的α-2-δ亚基结合，用于多种适应证，包括说明书标注的和未标注的。加巴喷丁的日总剂量为300至3600mg/d，一般分为3次服用。虽然加巴喷丁通常耐受性良好，但据报道其一种潜在的不良反应是外周水肿。然而，由于外周水肿的病因众多，在住院精神科病房可能会忽略药物引起的外周水肿。本文报告1例广泛性发育障碍和分裂情感性障碍患者，对加巴喷丁可能出现的药物不良反应（纳伦霍评分5分）识别延迟，表现为双侧疼痛性4级凹陷性水肿，且与剂量有明确关系。
