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通过病毒培养和宏基因组测序诊断的痘苗病毒向一名婴儿的接触传播。

Contact Transmission of Vaccinia to an Infant Diagnosed by Viral Culture and Metagenomic Sequencing.

作者信息

Martin Rebekah M, Burke Kristina, Verma Dinesh, Xie Heng, Langer Janine, Schlaberg Robert, Swaminathan Sankar, Hanson Kimberly E

机构信息

Department of Pathology, University of Utah, Salt Lake City, Utah, USA.

Associated Regional and University Pathologists, Inc. (ARUP Laboratories), Salt Lake City, Utah, USA.

出版信息

Open Forum Infect Dis. 2020 Mar 28;7(4):ofaa111. doi: 10.1093/ofid/ofaa111. eCollection 2020 Apr.

DOI:10.1093/ofid/ofaa111
PMID:32685604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7357282/
Abstract

Targeted molecular diagnostic tests and accurate immunoassays have transformed the landscape of clinical virology, calling into question the usefulness of traditional viral culture. Here we present a case where viral culture, followed by metagenomic sequencing, was central to the diagnosis of an unexpected viral infection, with significant clinical and public health implications.

摘要

靶向分子诊断测试和精确的免疫测定改变了临床病毒学的面貌，使传统病毒培养的实用性受到质疑。在此，我们报告一例病例，其中病毒培养继之以宏基因组测序，对一种意外病毒感染的诊断至关重要，具有重大的临床和公共卫生意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67ee/7357282/4ba1c967819d/ofaa111f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67ee/7357282/d44a0e4fa7a4/ofaa111f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67ee/7357282/2dce5ded979d/ofaa111f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67ee/7357282/4ba1c967819d/ofaa111f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67ee/7357282/d44a0e4fa7a4/ofaa111f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67ee/7357282/2dce5ded979d/ofaa111f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67ee/7357282/4ba1c967819d/ofaa111f0003.jpg

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本文引用的文献

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Phase 3 Efficacy Trial of Modified Vaccinia Ankara as a Vaccine against Smallpox.改良安卡拉牛痘疫苗作为天花疫苗的 3 期疗效试验。
N Engl J Med. 2019 Nov 14;381(20):1897-1908. doi: 10.1056/NEJMoa1817307.
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Use of Vaccinia Virus Smallpox Vaccine in Laboratory and Health Care Personnel at Risk for Occupational Exposure to Orthopoxviruses - Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2015.《在有职业性接触正痘病毒风险的实验室和医护人员中使用牛痘病毒天花疫苗——免疫实践咨询委员会（ACIP）的建议，2015 年》。
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痘苗病毒的遗传谱系与种群结构
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Clinical Pathogen Genomics.临床病原体基因组学。
Clin Lab Med. 2020 Dec;40(4):447-458. doi: 10.1016/j.cll.2020.08.003. Epub 2020 Oct 1.
Spironolactone blocks Epstein-Barr virus production by inhibiting EBV SM protein function.
螺内酯通过抑制EBV SM蛋白功能来阻断爱泼斯坦-巴尔病毒的产生。
Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3609-14. doi: 10.1073/pnas.1523686113. Epub 2016 Mar 14.
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Ebola virus: a clear and present danger.埃博拉病毒：一种迫在眉睫的危险。
J Clin Microbiol. 2015 Jan;53(1):4-8. doi: 10.1128/JCM.03115-14. Epub 2014 Nov 12.
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Secondary and tertiary transmission of vaccinia virus after sexual contact with a smallpox vaccinee--San Diego, California, 2012.2012 年加利福尼亚州圣地亚哥，天花疫苗接种者发生性接触后的牛痘病毒二次和三次传播。
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Point: is the era of viral culture over in the clinical microbiology laboratory?观点：病毒文化的时代是否已经在临床微生物学实验室结束？
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