Faculté de Pharmacie, IRD, APHM, MEPHI, Aix Marseille University, 19-21 Boulevard Jean Moulin, 13385 Marseille, France; Université Catholique de Bukavu (UCB), Hôpital Provincial Général de Référence de Bukavu, Bukavu, Congo.
Faculté de Pharmacie, IRD, APHM, MEPHI, Aix Marseille University, 19-21 Boulevard Jean Moulin, 13385 Marseille, France.
J Glob Antimicrob Resist. 2020 Sep;22:818-825. doi: 10.1016/j.jgar.2020.07.008. Epub 2020 Jul 18.
A review of literature was conducted to assess the prevalence and mechanisms of antibiotic resistance to date, mainly to β-lactam antibiotics, cephalosporins, carbapenems, colistin, and tigecycline in the Democratic Republic of the Congo (DRC). English and French publications were listed and analysed using PubMed/Medline, Google Scholar, and African Journals database between 1 January 1990 and 31 December 2019. For the 30 published articles found: (1) bacterial resistance to antibiotics concerned both Gram-negative and Gram-positive bacteria; (2) multidrug resistance prevalence was the same in half of Streptococcus pneumoniae isolates; (3) a worrying prevalence of methicillin-resistant Staphylococcus aureus (MRSA) was noted, which is associated with co-resistance to several other antibiotics; and (4) resistance to third-generation cephalosporins was very high in Enterobacteriaceae, mainly because of bla group and bla genes. Data on carbapenem and colistin resistance were not available in DRC until recently. Further work is required to set up a surveillance system for antibiotic resistance in DRC.
进行了文献回顾，以评估截至目前抗生素耐药性的流行情况和机制，主要涉及刚果民主共和国（DRC）的β-内酰胺类抗生素、头孢菌素类、碳青霉烯类、黏菌素和替加环素。使用 PubMed/Medline、Google Scholar 和 African Journals 数据库，检索了 1990 年 1 月 1 日至 2019 年 12 月 31 日的英文和法文出版物，并进行了分析。在已发表的 30 篇文章中：（1）抗生素耐药性既涉及革兰氏阴性菌也涉及革兰氏阳性菌；（2）在半数肺炎链球菌分离株中存在多重耐药性；（3）耐甲氧西林金黄色葡萄球菌（MRSA）的流行率令人担忧，它与对其他几种抗生素的共同耐药性有关；（4）肠杆菌科对第三代头孢菌素的耐药性非常高，主要是因为 bla 组和 bla 基因。直到最近，刚果民主共和国才出现关于碳青霉烯类和黏菌素耐药性的数据。需要进一步开展工作，在刚果民主共和国建立抗生素耐药性监测系统。
