Department of Thoracic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
BMC Pulm Med. 2020 Jul 20;20(1):198. doi: 10.1186/s12890-020-01235-2.
To systematically evaluate the correlation between percutaneous transthoracic needle biopsy (PTNB) and recurrence in stage I lung cancer.
The databases of PubMed, EMbase, The Cochrane Library, CNKI, WanFang Data and China Biology Medicine disc were retrieved to collect relevant literatures about the correlation between PTNB and recurrence in stage I lung cancer. The retrieval time was limited from the time of their database establishment to April 30/2020.Screened the literature, extracted the data and assessed the quality of studies included. Then the meta-analysis was performed by using Stata l6.0 software.
A total of 8 cohort studies involving 2760 lung cancer patients were included. The results of meta-analysis showed that PTNB did not increase the risk of total recurrence and pleural recurrence in the patients with stage I lung cancer. The result of subgroup analysis is according to the tumor location. For stage I lung cancer, PTNB will increase the risk of pleural recurrence in patients with sub-pleural lesions but not in those without sub-pleural lesions.
To stage I lung cancer, PTNB is not associated with the total recurrence and pleural recurrence but PTNB will increase the risk of pleural recurrence in patients with sub-pleural lesions.
系统评估经皮经胸穿刺活检（PTNB）与 I 期肺癌复发的相关性。
检索 PubMed、EMbase、The Cochrane Library、CNKI、万方数据和中国生物医学文献数据库，收集关于 PTNB 与 I 期肺癌复发相关性的相关文献。检索时间限定为各数据库建立时间至 2020 年 4 月 30 日。筛选文献、提取数据并评估纳入研究的质量。然后使用 Stata l6.0 软件进行荟萃分析。
共纳入 8 项队列研究，共 2760 例肺癌患者。荟萃分析结果表明，PTNB 不会增加 I 期肺癌患者总复发和胸膜复发的风险。亚组分析结果按肿瘤位置进行。对于 I 期肺癌，PTNB 会增加亚胸膜病变患者的胸膜复发风险，但不会增加无亚胸膜病变患者的胸膜复发风险。
对于 I 期肺癌，PTNB 与总复发和胸膜复发无关，但会增加亚胸膜病变患者的胸膜复发风险。
