Sulyok E, Sólyom J, Füller M, Kerekes L
County Children's Hospital, Pécs.
Acta Paediatr Hung. 1988;29(3-4):239-43.
Blood spot 17OH-P concentrations were determined in 14 healthy premature (mean birthweight 1439 g, mean gestational age 30 weeks) and full-term newborn infants (mean birthweight 3532 g, mean gestational age 39.2 weeks) during the first five weeks of life to provide reference data for infants with various gestational and postnatal ages. It was demonstrated that with advancing age there was an abrupt fall in 17OH-P from 296.2 +/- 84.1 nmol/l on the first day to 101.2 +/- 19.5 nmol/l on the 7th day (p less than 0.001) and 75.7 +/- 8.7 nmol/l (p less than 0.05) on the 14th day in premature infants. In full-term neonates its initial value is much lower (90.1 +/- 12.5 nmol/l) and its fall during the first week is much less pronounced (51.5 +/- 6.5 nmol/l, p less than 0.01). Comparing the postnatal changes in 17OH-P in the two groups it proved to be significantly higher in premature than in full-term infants at all ages except for the 4th week. When blood spot 17OH-P values were studied as a function of gestational age at the age of 5 days a significant inverse relationship was found between the two parameters. It is assumed that in addition to placental 17OH-P production and perinatal stress, renal salt wasting may also account for the long lasting elevation of 17OH-P plasma level seen in premature infants.
对14名健康的早产（平均出生体重1439克，平均胎龄30周）和足月新生儿（平均出生体重3532克，平均胎龄39.2周）在出生后的前五周测定血斑17-羟孕酮（17OH-P）浓度，以提供不同胎龄和出生后年龄婴儿的参考数据。结果表明，随着年龄增长，早产婴儿的17OH-P从出生第一天的296.2±84.1纳摩尔/升急剧下降至第7天的101.2±19.5纳摩尔/升（p<0.001），第14天降至75.7±8.7纳摩尔/升（p<0.05）。足月新生儿其初始值低得多（90.1±12.5纳摩尔/升），且在第一周的下降不太明显（51.5±6.5纳摩尔/升，p<0.01）。比较两组17OH-P的出生后变化，除第4周外，在所有年龄段早产婴儿的17OH-P均显著高于足月婴儿。当研究出生5天时血斑17OH-P值与胎龄的关系时，发现这两个参数之间存在显著的负相关。据推测，除了胎盘产生17OH-P和围产期应激外，肾失盐也可能是早产婴儿血浆17OH-P水平长期升高的原因。
