School of Pharmacy University of Nottingham Malaysia, Semenyih, -43500, Selangor, Malaysia.
Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh-30450 Perak, Malaysia.
Curr Pharm Des. 2020;26(34):4272-4276. doi: 10.2174/1381612826666200720235752.
Cancer and tumor have been major reasons for numerous deaths in this century across the world. Many strategies have been designed to treat, diagnose, or prevent cancer. The success of chemotherapy largely depends on drug targeting. The advent of nanotechnology has vastly improved drug delivery for targeting and diagnosis. Nevertheless, the accuracy of drug targeting with polymeric nanoparticles has always been questionable. The polymeric nanoparticles synthesized from varieties of lipid-based compounds or combined with vectors, such as liposomes, ethosomes, and transfersomes, may allow the drug to overcome the issue of resistance to drug absorption in biological membranes. The combined effects of lipid-based nanocarriers are known to improve the efficacy and accuracy of polymeric nanoparticles. The present review explores the application of lipid based nanocarriers in the treatment and diagnosis of cancer A special focus is given to the use of lipid-based nanocarriers in the treatment, diagnosis, and mitigation of cancer located in blood, brain, lung, and colon. The treatment of these cancers has always been questionable as the chances of relapse are very high. The review encompasses the use of lipid-based nanocarriers in targeting tissue-specific cancer cells.
癌症和肿瘤一直是本世纪全球众多死亡的主要原因。许多策略被设计用来治疗、诊断或预防癌症。化疗的成功在很大程度上取决于药物靶向。纳米技术的出现极大地改善了药物靶向和诊断的传递。然而，聚合物纳米粒子的药物靶向的准确性一直存在疑问。由各种基于脂质的化合物合成或与载体（如脂质体、醇质体和转质体）结合的聚合物纳米粒子，可以使药物克服生物膜对药物吸收的耐药性问题。基于脂质的纳米载体的联合作用被认为可以提高聚合物纳米粒子的疗效和准确性。本综述探讨了基于脂质的纳米载体在癌症治疗和诊断中的应用，特别关注了基于脂质的纳米载体在治疗、诊断和减轻血液、大脑、肺和结肠中癌症的应用。由于复发的可能性很高，这些癌症的治疗一直存在疑问。该综述包括了基于脂质的纳米载体在靶向组织特异性癌细胞中的应用。
