Suppr超能文献

癌症诊断与治疗中的纳米技术

Nanotechnology in Cancer Diagnosis and Treatment.

作者信息

Alrushaid Noor, Khan Firdos Alam, Al-Suhaimi Ebtesam Abdullah, Elaissari Abdelhamid

机构信息

Department of Stem Cell Biology, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.

Univ. Lyon, University Claude Bernard Lyon-1, CNRS, ISA-UMR 5280, 69622 Lyon, France.

出版信息

Pharmaceutics. 2023 Mar 22;15(3):1025. doi: 10.3390/pharmaceutics15031025.

Abstract

Traditional cancer diagnosis has been aided by the application of nanoparticles (NPs), which have made the process easier and faster. NPs possess exceptional properties such as a larger surface area, higher volume proportion, and better targeting capabilities. Additionally, their low toxic effect on healthy cells enhances their bioavailability and -half by allowing them to functionally penetrate the fenestration of epithelium and tissues. These particles have attracted attention in multidisciplinary areas, making them the most promising materials in many biomedical applications, especially in the treatment and diagnosis of various diseases. Today, many drugs are presented or coated with nanoparticles for the direct targeting of tumors or diseased organs without harming normal tissues/cells. Many types of nanoparticles, such as metallic, magnetic, polymeric, metal oxide, quantum dots, graphene, fullerene, liposomes, carbon nanotubes, and dendrimers, have potential applications in cancer treatment and diagnosis. In many studies, nanoparticles have been reported to show intrinsic anticancer activity due to their antioxidant action and cause an inhibitory effect on the growth of tumors. Moreover, nanoparticles can facilitate the controlled release of drugs and increase drug release efficiency with fewer side effects. Nanomaterials such as microbubbles are used as molecular imaging agents for ultrasound imaging. This review discusses the various types of nanoparticles that are commonly used in cancer diagnosis and treatment.

摘要

纳米颗粒(NPs)的应用辅助了传统癌症诊断,使这一过程更轻松、更快速。纳米颗粒具有诸如更大的表面积、更高的体积占比以及更好的靶向能力等卓越特性。此外,它们对健康细胞的低毒性作用通过使其能够功能性地穿透上皮和组织的窗孔来提高其生物利用度和半衰期。这些颗粒在多学科领域引起了关注,使其成为许多生物医学应用中最有前景的材料,尤其是在各种疾病的治疗和诊断方面。如今,许多药物都呈现为纳米颗粒形式或包覆有纳米颗粒,以便直接靶向肿瘤或患病器官而不损害正常组织/细胞。许多类型的纳米颗粒,如金属纳米颗粒、磁性纳米颗粒、聚合物纳米颗粒、金属氧化物纳米颗粒、量子点、石墨烯、富勒烯、脂质体、碳纳米管和树枝状大分子,在癌症治疗和诊断中都有潜在应用。在许多研究中,据报道纳米颗粒因其抗氧化作用而显示出内在的抗癌活性,并对肿瘤生长产生抑制作用。此外,纳米颗粒可以促进药物的控释并提高药物释放效率,同时副作用更少。诸如微泡等纳米材料被用作超声成像的分子成像剂。本综述讨论了常用于癌症诊断和治疗的各种类型的纳米颗粒。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdbb/10052895/8ff111c8a439/pharmaceutics-15-01025-g001.jpg

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验