Institute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, China.
Priority Area Asthma & Allergy, Research Center Borstel, Airway Research Center North (ARCN), Members of the German Center for Lung Research (DZL), Borstel, Germany.
Front Immunol. 2020 Jun 30;11:1158. doi: 10.3389/fimmu.2020.01158. eCollection 2020.
Sjögren's syndrome (SS) is a complex rheumatoid disease that mainly affects exocrine glands, resulting in xerostomia (dry mouth) and xerophthalmia (dry eye). SS is characterized by autoantibodies, infiltration into exocrine glands, and ectopic expression of MHC II molecules on glandular epithelial cells. In contrast to the well-characterized clinical and immunological features, the etiology and pathogenesis of SS remain largely unknown. Animal models are powerful research tools for elucidating the pathogenesis of human diseases. To date, many mouse models of SS, including induced models, in which disease is induced in mice, and genetic models, in which mice spontaneously develop SS-like disease, have been established. These mouse models have provided new insight into the pathogenesis of SS. In this review, we aim to provide a comprehensive overview of recent advances in the field of experimental SS.
干燥综合征（SS）是一种复杂的类风湿疾病，主要影响外分泌腺，导致口干（口干）和干眼病（干眼症）。SS 的特征是自身抗体、外分泌腺浸润和 MHC II 分子在腺上皮细胞上的异位表达。与特征明确的临床和免疫学特征相比，SS 的病因和发病机制在很大程度上仍不清楚。动物模型是阐明人类疾病发病机制的有力研究工具。迄今为止，已经建立了许多 SS 的小鼠模型，包括诱导模型，即在小鼠中诱导疾病，以及遗传模型，即小鼠自发发展出类似 SS 的疾病。这些小鼠模型为 SS 的发病机制提供了新的见解。在这篇综述中，我们旨在全面概述实验性 SS 领域的最新进展。
