Crystal structures of three platinacyclic complexes bearing isopropyl eugenoxyacetate and pyridine derivatives.

Three new platinum(II) complexes bearing a eugenol and a pyridine derivative, namely (η-2-allyl-4-meth-oxy-5-{[(propan-2-yl-oxy)carbon-yl]meth-oxy}phenyl-κ )chlorido-(pyridine-κ)platinum(II), [Pt(CHO)Cl(CHN)], (), (η-2-allyl-4-meth-oxy-5-{[(propan-2-yl-oxy)carbon-yl]meth-oxy}phenyl-κ )chlorido-(4-methyl-pyridine-κ)platinum(II), [Pt(CHO)Cl(CHN)], (), and (η-2-allyl-4-meth-oxy-5-{[(propan-2-yl-oxy)carbon-yl]meth-oxy}phenyl-κ )chlorido(pyridine-4-carb-oxy-lic acid-κ)platinum(II), [Pt(CHO)Cl(CHNO)], (), have been synthesized and further characterized by single-crystal X-ray diffraction. The Pt atoms exhibit the usual distorted square-planar coordination and are surrounded by one Cl atom, one N atom, and a C atom and C=C double bond of the eugenol ligand. The donor N atom of the pyridine ligand occupies a position with respect to the double bond. Complexes () and () crystallize isomorphously in space group and display a similar crystal packing characterized by C-H⋯O hydrogen bonding, C-H⋯π and π-π inter-actions. However, the presence of the additional methyl group in the 4-methyl-pyridine ligand in () disturbs the π-π inter-actions. The crystal packing of () is characterized by O-H⋯O hydrogen bonding, resulting in the formation of chains of mol-ecules connected in a head-to-tail fashion and running in the [101] direction. The IC values for the HepG2 and KB cell lines are 150.9, 122.3 µ for () and 138.9, 93.2 µ for (), respectively.