Clouston Sean A P, Deri Yael, Horton Megan, Tang Cheuk, Diminich Erica, DeLorenzo Christine, Kritikos Minos, Pellecchia Alison C, Santiago-Michels Stephanie, Carr Melissa A, Gandy Samuel, Sano Mary, Bromet Evelyn J, Lucchini Roberto G, Luft Benjamin J
Program in Public Health Department of Family, Population, and Preventive Medicine Renaissance School of Medicine at Stony Brook University Stony Brook New York USA.
Department of Medicine Renaissance School of Medicine at Stony Brook University Stony Brook New York USA.
Alzheimers Dement (Amst). 2020 Jul 13;12(1):e12059. doi: 10.1002/dad2.12059. eCollection 2020.
This study examined cortical thickness (CTX) in World Trade Center (WTC) responders with cognitive impairment (CI).
WTC responders (N = 99) with/without CI, recruited from an epidemiologic study, completed a T1-MPRAGE protocol. CTX was automatically computed in 34 regions of interest. Region-based and surface-based morphometry examined CTX in CI versus unimpaired responders. CTX was automatically computed in 34 regions of interest. Region-based measures were also compared to published norms.
Participants were 55.8 (SD = 0.52) years old; 48 had CI. Compared to unimpaired responders, global mean CTX was reduced in CI and across 21/34 cortical subregions. Surface-based analyses revealed reduced CTX across frontal, temporal, and parietal lobes when adjusting for multiple comparisons. Both CI and unimpaired WTC groups had reduced CTX in the entorhinal and temporal cortices compared to published normative data.
Results from the first structural magnetic resonance imaging study in WTC responders identified reduced CTX consistent with a neurodegenerative disease of unknown etiology.
本研究调查了患有认知障碍（CI）的世贸中心（WTC）应急人员的皮质厚度（CTX）。
从一项流行病学研究中招募了99名有/无CI的WTC应急人员，他们完成了一项T1加权磁化准备快速梯度回波（T1-MPRAGE）方案。在34个感兴趣区域自动计算CTX。基于区域和基于表面的形态测量法检查了CI患者与未受损应急人员的CTX。在34个感兴趣区域自动计算CTX。基于区域的测量结果也与已发表的标准进行了比较。
参与者的年龄为55.8岁（标准差=0.52）；48人患有CI。与未受损的应急人员相比，CI患者的全脑平均CTX以及21/34个皮质亚区域的CTX均降低。基于表面的分析显示，在进行多重比较校正后，额叶、颞叶和顶叶的CTX降低。与已发表的标准数据相比，CI组和未受损的WTC组在内嗅皮质和颞叶皮质的CTX均降低。
对WTC应急人员进行的首次结构磁共振成像研究结果表明，CTX降低与病因不明的神经退行性疾病一致。
