Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.
Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.
Nat Prod Res. 2022 Mar;36(6):1616-1620. doi: 10.1080/14786419.2021.1887868. Epub 2021 Feb 22.
New propene derivative 1-(3,4-methylenedioxyphenyl)-2-(2-hydroxy-5-(3-hydroxypropyl)-3-methoxyphenyl)prop-2-en-1-one (), along with three known triterpenoids ursolic acid (), pomolic acid (), and maslinic acid () were isolated from the leaves of species. All structures were assigned by spectroscopic analysis. Compound showed potent cytotoxicity against four cancer cell lines (KB, HepG2, Lu, and MCF7) with the IC values of 3.19, 2.87, 2.33, and 2.44 µM, respectively.
从 种的叶子中分离得到了一种新的丙烯衍生物 1-(3,4-亚甲二氧基苯基)-2-(2-羟基-5-(3-羟基丙基)-3-甲氧基苯基)丙-2-烯-1-酮 ()，以及三种已知的三萜酸 熊果酸 ()、齐墩果酸 ()和马桑酸 ()。所有结构均通过光谱分析确定。化合物 对四种癌细胞系（KB、HepG2、Lu 和 MCF7）表现出强烈的细胞毒性，其 IC 值分别为 3.19、2.87、2.33 和 2.44 μM。
