Brasili Francesco, Capocefalo Angela, Palmieri Damiano, Capitani Francesco, Chiessi Ester, Paradossi Gaio, Bordi Federico, Domenici Fabio
Dipartimento di Fisica, Sapienza Università di Roma, Piazzale Aldo Moro 5, 00185 Rome, Italy; Dipartimento di Scienze e Tecnologie Chimiche, Università di Roma Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.
Dipartimento di Fisica, Sapienza Università di Roma, Piazzale Aldo Moro 5, 00185 Rome, Italy.
J Colloid Interface Sci. 2020 Nov 15;580:419-428. doi: 10.1016/j.jcis.2020.07.006. Epub 2020 Jul 8.
We realise an antibacterial nanomaterial based on the self-limited assembly of patchy plasmonic colloids, obtained by adsorption of lysozyme to gold nanoparticles. The possibility of selecting the size of the assemblies within several hundred nanometres allows for tuning their optical response in a wide range of frequencies from visible to near infrared. We also demonstrate an aggregation-dependent modulation of the catalytic activity, which results in an enhancement of the antibacterial performances for assemblies of the proper size. The gained overall control on structure, optical properties and biological activity of such nanomaterial paves the way for the development of novel antibacterial nanozymes with promising applications in treating multi drug resistant bacteria.
我们通过将溶菌酶吸附到金纳米颗粒上，实现了一种基于片状等离子体胶体自限组装的抗菌纳米材料。能够在几百纳米范围内选择组装体的尺寸，这使得我们可以在从可见光到近红外的广泛频率范围内调节其光学响应。我们还展示了催化活性的聚集依赖性调制，这导致了适当尺寸组装体的抗菌性能增强。对这种纳米材料的结构、光学性质和生物活性所获得的全面控制，为开发在治疗多重耐药细菌方面具有广阔应用前景的新型抗菌纳米酶铺平了道路。
