Instituto de Hortofruticultura Subtropical y Mediterránea "La Mayora" (IHSM-UMA-CSIC), Departamento de Genética, Facultad de Ciencias, Universidad de Málaga, Campus de Teatinos s/n, E-29071 Málaga, Spain.
Curr Opin Virol. 2020 Jun;42:58-64. doi: 10.1016/j.coviro.2020.06.004. Epub 2020 Jul 19.
Geminiviruses (viruses with circular, single-stranded DNA genomes) are one of the major groups of plant viruses causing severe economic problems for agriculture worldwide. The control of these pathogens has become a priority to maintain the production of important crops, including cotton, maize, cassava, and other vegetables. Obtaining resistant plants is the most powerful strategy and a key factor to stablish an effective integrated pest management for a robust control. In the last few decades, numerous studies have successfully approached that goal using diverse strategies based on plant variability or on the engineered expression of proteins/RNAs. The increasing knowledge of the mechanisms involved in the geminivirus-plant-vector interactions, in combination with the development of gene editing technology and nanoparticles, draw new and promising strategies for a durable control of these emerging pathogens.
双生病毒（具有环状、单链 DNA 基因组的病毒）是引起全球农业严重经济问题的主要植物病毒群之一。控制这些病原体已成为维持棉花、玉米、木薯和其他蔬菜等重要作物生产的首要任务。获得抗性植物是最有力的策略，也是建立有效的综合虫害管理以进行有效控制的关键因素。在过去几十年中，许多研究成功地使用基于植物变异性或蛋白质/RNA 工程表达的各种策略来实现这一目标。对双生病毒-植物-载体相互作用中涉及的机制的深入了解，结合基因编辑技术和纳米粒子的发展，为这些新兴病原体的持久控制提供了新的、有前景的策略。
