Key Laboratory of Drug-Targeting and Drug-Delivery Systems of the Ministry of Education, Department of Medicinal Chemistry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.
Key Laboratory of Drug-Targeting and Drug-Delivery Systems of the Ministry of Education, Department of Medicinal Chemistry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.
Eur J Med Chem. 2020 Oct 1;203:112577. doi: 10.1016/j.ejmech.2020.112577. Epub 2020 Jul 15.
Spirodienone derivatives have unique structural characteristics. Its spiroatoms are quaternary carbons that act as bridges between dienone and four, five, six and even seven heterocycles or carbon rings. The structural unit not only shows unique properties in organic chemistry but also demonstrates a variety of biological activities. Herein, we overviewed the biological activities and the synthesis methods of spirodienone derivatives for the first time, hoping to benefit the development and design based on novel drugs of spirodienone derivatives. The spirodienone derivatives discussed in this review included spirolactam, spirocarbon rings and spiroheterocycles, where 4-or 6-are spirocyclic atoms (Fig. 1).
螺二烯酮衍生物具有独特的结构特征。其螺原子为季碳原子，在二烯酮和四个、五个、六个甚至七个杂环或碳环之间起到桥梁作用。该结构单元不仅在有机化学中表现出独特的性质，而且还展现出多种生物活性。在此，我们首次综述了螺二烯酮衍生物的生物活性和合成方法，希望为新型螺二烯酮衍生物药物的开发和设计提供参考。本文讨论的螺二烯酮衍生物包括螺内酰胺、螺碳环和螺杂环，其中 4-或 6-为螺环原子（图 1）。
