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使用具有复合三维电极的微流控芯片进行粒子的介电泳分离

Dielectrophoretic Separation of Particles Using Microfluidic Chip with Composite Three-Dimensional Electrode.

作者信息

Chen Li, Liu Xing, Zheng Xiaolin, Zhang Xiaoling, Yang Jun, Tian Tian, Liao Yanjian

机构信息

Key Laboratory of Biorheological Science and Technology, Chongqing University, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400030, China.

出版信息

Micromachines (Basel). 2020 Jul 20;11(7):700. doi: 10.3390/mi11070700.

DOI:10.3390/mi11070700
PMID:32698449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7407815/
Abstract

Integrating three-dimensional (3D) microelectrodes on microfluidic chips based on polydimethylsiloxane (PDMS) has been a challenge. This paper introduces a composite 3D electrode composed of Ag powder (particle size of 10 nm) and PDMS. Ethyl acetate is added as an auxiliary dispersant during the compounding process. A micromachining technique for processing 3D microelectrodes of any shape and size was developed to allow the electrodes to be firmly bonded to the PDMS chip. Through theoretical calculations, numerical simulations, and experimental verification, the role of the composite 3D microelectrodes in separating polystyrene particles of three different sizes via dielectrophoresis was systematically studied. This microfluidic device separated 20-, 10-, and 5-μm polystyrene particles nondestructively, efficiently, and accurately.

摘要

在基于聚二甲基硅氧烷(PDMS)的微流控芯片上集成三维(3D)微电极一直是一项挑战。本文介绍了一种由银粉(粒径为10纳米)和PDMS组成的复合3D电极。在复合过程中添加乙酸乙酯作为辅助分散剂。开发了一种用于加工任意形状和尺寸的3D微电极的微加工技术,以使电极能够牢固地粘结到PDMS芯片上。通过理论计算、数值模拟和实验验证,系统研究了复合3D微电极在通过介电泳分离三种不同尺寸聚苯乙烯颗粒中的作用。该微流控装置能够无损、高效且准确地分离20微米、10微米和5微米的聚苯乙烯颗粒。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c079/7407815/8acb8f26df18/micromachines-11-00700-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c079/7407815/fe6a9c6e15d2/micromachines-11-00700-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c079/7407815/0b6f82a29ae7/micromachines-11-00700-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c079/7407815/bb640f3c02b1/micromachines-11-00700-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c079/7407815/af63e8c158a1/micromachines-11-00700-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c079/7407815/8acb8f26df18/micromachines-11-00700-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c079/7407815/fe6a9c6e15d2/micromachines-11-00700-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c079/7407815/0b6f82a29ae7/micromachines-11-00700-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c079/7407815/bb640f3c02b1/micromachines-11-00700-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c079/7407815/af63e8c158a1/micromachines-11-00700-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c079/7407815/8acb8f26df18/micromachines-11-00700-g005.jpg

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