Department of Obstetrics & Gynecology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
SOBAJIMA Clinic, Osaka, Japan.
Regen Med. 2020 Jul;15(7):1891-1904. doi: 10.2217/rme-2020-0037. Epub 2020 Jul 23.
Embryo implantation and subsequent pregnancy depends on endometrial thickness. To investigate potential fertility strategies for women with thin endometrium, we explored the efficacy of adipose tissue-derived regenerative cells (ADRCs) on thin endometrium and embryo implantation in a mouse model. ADRCs isolated from mouse subcutaneous fat were characterized by flow cytometry. Endometrium thickness, endometrial fibrosis, embryo implantation and angiogenesis factors were evaluated in uterine cavities of ethanol-induced thin endometrium mice with ADRC transplantation. ADRCs included adipose-derived stem cells and some blood vessel component cells. ADRCs improved endometrial thickness, endometrial fibrosis and embryo implantation and augmented vascular endothelial growth factor expression in the mouse uterine. ADRCs may be a useful therapeutic strategy to improve fertility of women with thin endometrium.
胚胎着床和随后的妊娠取决于子宫内膜的厚度。为了研究薄型子宫内膜女性潜在的生育策略，我们在小鼠模型中探讨了脂肪组织来源的再生细胞（ADRCs）对薄型子宫内膜和胚胎着床的疗效。 从小鼠皮下脂肪中分离出的 ADRCs 通过流式细胞术进行了鉴定。通过 ADRC 移植，评估了乙醇诱导的薄型子宫内膜小鼠子宫腔中的子宫内膜厚度、子宫内膜纤维化、胚胎着床和血管生成因子。ADRCs 包括脂肪来源的干细胞和一些血管成分细胞。ADRCs 改善了小鼠子宫中的子宫内膜厚度、子宫内膜纤维化和胚胎着床，并增加了血管内皮生长因子的表达。ADRCs 可能是改善薄型子宫内膜女性生育能力的一种有用的治疗策略。
