2014-2018 年中国湖北省输入性卵形疟原虫和间日疟原虫的特征。

Characteristics of imported Plasmodium ovale spp. and Plasmodium malariae in Hubei Province, China, 2014-2018.

机构信息

Institute of Parasitic Disease Control, Hubei Provincial Center for Disease Control and Prevention, Wuhan, 430079, China.

出版信息

Malar J. 2020 Jul 22;19(1):264. doi: 10.1186/s12936-020-03337-y.

DOI:10.1186/s12936-020-03337-y

PMID:32698906

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7374957/

Abstract

BACKGROUND

There have been an increasing number of imported cases of malaria in Hubei Province in recent years. In particular, the number of cases of Plasmodium ovale spp. and Plasmodium malariae significantly increased, which resulted in increased risks during the malaria elimination phase. The purpose of this study was to acquire a better understanding of the epidemiological characteristics of P. ovale spp. and P. malariae imported to Hubei Province, China, so as to improve case management.

METHODS

Data on all malaria cases from January 2014 to December 2018 in Hubei Province were extracted from the China national diseases surveillance information system (CNDSIS). This descriptive study was conducted to analyse the prevalence trends, latency periods, interval from onset of illness to diagnosis, and misdiagnosis of cases of P. ovale spp. and P. malariae malaria.

RESULTS

During this period, 634 imported malaria cases were reported, of which 87 P. ovale spp. (61 P. ovale curtisi and 26 P. ovale wallikeri) and 18 P. malariae cases were confirmed. The latency periods of P. ovale spp., P. malariae, Plasmodium vivax, and Plasmodium falciparum differed significantly, whereas those of P. ovale curtisi and P. ovale wallikeri were no significant difference. The proportion of correct diagnosis of P. ovale spp. and P. malariae malaria cases were 48.3% and 44.4%, respectively, in the hospital or lower-level Centers for Disease Control and Prevention (CDC). In the Provincial Reference Laboratory, the sensitivity of microscopy and rapid diagnostic tests was 94.3% and 70.1%, respectively, for detecting P. ovale spp., and 88.9% and 38.9%, respectively, for detecting P. malariae. Overall, 97.7% (85/87) of P. ovale spp. cases and 94.4% (17/18) of P. malariae cases originated from Africa.

CONCLUSION

The increase in the number of imported P. ovale spp. and P. malariae cases, long latency periods, and misdiagnosis pose a challenge to this region. Therefore, more attention should be paid to surveillance of imported cases of P. ovale spp. and P. malariae infection to reduce the burden of public health and potential risk of malaria.

摘要

背景

近年来，湖北省的输入性疟疾病例不断增加。特别是卵形疟原虫和间日疟原虫的病例数显著增加，这导致了在消除疟疾阶段的风险增加。本研究的目的是更好地了解中国湖北省输入性卵形疟原虫和间日疟原虫的流行病学特征，以便改进病例管理。

方法

从中国国家疾病监测信息系统（CNDSIS）中提取 2014 年 1 月至 2018 年 12 月湖北省所有疟疾病例的数据。本研究采用描述性研究方法，分析卵形疟原虫和间日疟原虫疟疾病例的流行趋势、潜伏期、发病至诊断的间隔时间以及误诊情况。

结果

在此期间，报告了 634 例输入性疟疾病例，其中 87 例为卵形疟原虫（61 例卵形疟原虫 curtisi 和 26 例卵形疟原虫 wallikeri）和 18 例间日疟原虫病例。卵形疟原虫、间日疟原虫、间日疟原虫和恶性疟原虫的潜伏期差异有统计学意义，而卵形疟原虫 curtisi 和卵形疟原虫 wallikeri 之间则无显著差异。在医院或下级疾病预防控制中心（CDC），卵形疟原虫和间日疟原虫疟疾病例的正确诊断比例分别为 48.3%和 44.4%。在省级参考实验室，显微镜和快速诊断检测检测卵形疟原虫的灵敏度分别为 94.3%和 70.1%，检测间日疟原虫的灵敏度分别为 88.9%和 38.9%。总的来说，87 例卵形疟原虫病例中有 97.7%（85/87）和 18 例间日疟原虫病例中有 94.4%（17/18）来自非洲。