Hippo 通路在器官发育、稳态和再生中的作用。
The Hippo pathway in organ development, homeostasis, and regeneration.
机构信息
Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, United States.
Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, United States.
出版信息
Curr Opin Cell Biol. 2017 Dec;49:99-107. doi: 10.1016/j.ceb.2017.12.012. Epub 2018 Jan 6.
Abstract
The Hippo pathway is a universal governor of organ size, tissue homeostasis, and regeneration. A growing body of work has advanced our understanding of Hippo pathway regulation of cell proliferation, differentiation, and spatial patterning not only in organ development but also upon injury-induced regeneration. The pathway's central role in stem cell biology thus implicates its potential for therapeutic manipulation in mammalian organ regeneration. In this review, we survey recent literature linking the Hippo pathway to the development, homeostasis, and regeneration of various organs, including Hippo-independent roles for YAP, defined here as YAP functions that are not regulated by the Hippo pathway kinases LATS1/2.
摘要
Hippo 通路是器官大小、组织稳态和再生的普遍调节因子。越来越多的研究工作增进了我们对 Hippo 通路调节细胞增殖、分化和空间模式的理解，不仅在器官发育中，而且在损伤诱导的再生中也是如此。该通路在干细胞生物学中的核心作用表明其有可能在哺乳动物器官再生的治疗干预中发挥作用。在这篇综述中，我们调查了最近将 Hippo 通路与各种器官的发育、稳态和再生联系起来的文献，包括 YAP 的 Hippo 非依赖性作用，这里定义为不受 Hippo 通路激酶 LATS1/2 调节的 YAP 功能。
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本文引用的文献
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Yorkie is required to restrict the injury responses in planarians.Yorkie基因对于限制涡虫的损伤反应是必需的。
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YAP determines the cell fate of injured mouse hepatocytes in vivo.YAP 决定体内受损的小鼠肝细胞的细胞命运。
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Dystrophin-glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation.肌营养不良蛋白-糖蛋白复合物隔离Yes相关蛋白以抑制心肌细胞增殖。
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Expression and localization of Yap and Taz during development of the mandibular first molar in rats.Yap和Taz在大鼠下颌第一磨牙发育过程中的表达及定位
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YAP promotes myogenic differentiation the MEK5-ERK5 pathway.YAP 通过MEK5-ERK5 通路促进肌源性分化。
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Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth.Amotl1 介导将 Hippo 效应因子 Yap1 隔离在 Fat4 下游，以限制心脏生长。
Nat Commun. 2017 Feb 27;8:14582. doi: 10.1038/ncomms14582.
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Snail/Slug-YAP/TAZ complexes cooperatively regulate mesenchymal stem cell function and bone formation.蜗牛/蛞蝓-YAP/TAZ复合物协同调节间充质干细胞功能和骨形成。
Cell Cycle. 2017 Mar 4;16(5):399-405. doi: 10.1080/15384101.2017.1280643. Epub 2017 Jan 23.
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The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα.河马激酶LATS1和LATS2通过与雌激素受体α相互作用来控制人类乳腺细胞的命运。
Nature. 2017 Jan 26;541(7638):541-545. doi: 10.1038/nature20829. Epub 2017 Jan 9.
9
CDK5RAP2 interaction with components of the Hippo signaling pathway may play a role in primary microcephaly.CDK5RAP2与Hippo信号通路的组成部分相互作用可能在原发性小头畸形中起作用。
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Prostaglandin E Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice.前列腺素E激活YAP和一个正向信号回路，以促进结肠炎后小鼠结肠的再生，但也会促进小鼠的癌症发生。
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