Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, United States.
Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, United States.
Curr Opin Cell Biol. 2017 Dec;49:99-107. doi: 10.1016/j.ceb.2017.12.012. Epub 2018 Jan 6.
The Hippo pathway is a universal governor of organ size, tissue homeostasis, and regeneration. A growing body of work has advanced our understanding of Hippo pathway regulation of cell proliferation, differentiation, and spatial patterning not only in organ development but also upon injury-induced regeneration. The pathway's central role in stem cell biology thus implicates its potential for therapeutic manipulation in mammalian organ regeneration. In this review, we survey recent literature linking the Hippo pathway to the development, homeostasis, and regeneration of various organs, including Hippo-independent roles for YAP, defined here as YAP functions that are not regulated by the Hippo pathway kinases LATS1/2.
Hippo 通路是器官大小、组织稳态和再生的普遍调节因子。越来越多的研究工作增进了我们对 Hippo 通路调节细胞增殖、分化和空间模式的理解，不仅在器官发育中，而且在损伤诱导的再生中也是如此。该通路在干细胞生物学中的核心作用表明其有可能在哺乳动物器官再生的治疗干预中发挥作用。在这篇综述中，我们调查了最近将 Hippo 通路与各种器官的发育、稳态和再生联系起来的文献，包括 YAP 的 Hippo 非依赖性作用，这里定义为不受 Hippo 通路激酶 LATS1/2 调节的 YAP 功能。
