Pak J Biol Sci. 2020 Jan;23(7):911-916. doi: 10.3923/pjbs.2020.911.916.
Rhopalaea is a genus of ascidian belonging to the family Diazonidae. Ascidians provide niches for various microorganisms including fungi. This present study describes the potential new source for natural bioactive compounds from Rhopalaea-associated fungi obtained from Bunaken marine park.
As part of an on-going research program to explore the chemical diversity of marine derived fungi, we performed an antimicrobial bioactivity-guided screening of EtOAc extracts of the fungi isolated from ascidian Rhopalaea sp.
The study confirms that the ascidian obtained from Bunaken marine park was Rhopalaea sp. The fungus isolated from the ascidian was Aspergillus flavus which showed antimicrobial activity against bacteria Escherichia coli, Staphylococcus aereus, Aeromonas hydrophila and antifungal against the human pathogenic fungus Candida albicans.
Aspergillus flavus isolated from ascidian Rhopalaea sp. has the potential as antibacterial and antifungal.
枝鳃樽海鞘是属于樽海鞘科的一类海鞘。海鞘为各种微生物（包括真菌）提供了小生境。本研究描述了从布纳肯海洋公园采集的枝鳃樽海鞘相关真菌中获得的天然生物活性化合物的潜在新来源。
作为探索海洋来源真菌化学多样性的正在进行的研究计划的一部分，我们对从枝鳃樽海鞘 Rhopalaea sp 中分离的真菌的 EtOAc 提取物进行了抗微生物生物活性导向筛选。
研究证实，从布纳肯海洋公园获得的海鞘为枝鳃樽海鞘 Rhopalaea sp。从海鞘中分离出的真菌为黄曲霉，该真菌对细菌大肠杆菌、金黄色葡萄球菌、嗜水气单胞菌具有抗菌活性，对人类致病性真菌白色念珠菌具有抗真菌活性。
从枝鳃樽海鞘 Rhopalaea sp. 中分离出的黄曲霉具有抗菌和抗真菌的潜力。
